Viral rewiring of cellular lipid metabolism to create membranous replication compartments

Jeroen Rpm Strating; Frank Jm van Kuppeveld

doi:10.1016/j.ceb.2017.02.005

Viral rewiring of cellular lipid metabolism to create membranous replication compartments

Jeroen Rpm Strating, Frank Jm van Kuppeveld

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid metabolism. Disparate viruses have many commonalities as well as disparities in their interactions with the host lipidome and accumulate specific sets of lipids (sterols, glycerophospholipids, sphingolipids) at their VRCs. Recent years have seen an upsurge in studies investigating the role of lipids in +RNA virus replication, in particular of sterols, and uncovered that membrane contact sites and lipid transfer proteins are hijacked by viruses and play pivotal roles in VRC formation.

Original language	English
Pages (from-to)	24-33
Number of pages	10
Journal	Current Opinion in Cell Biology
Volume	47
DOIs	https://doi.org/10.1016/j.ceb.2017.02.005
Publication status	Published - 24 Feb 2017

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title = "Viral rewiring of cellular lipid metabolism to create membranous replication compartments",

abstract = "Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid metabolism. Disparate viruses have many commonalities as well as disparities in their interactions with the host lipidome and accumulate specific sets of lipids (sterols, glycerophospholipids, sphingolipids) at their VRCs. Recent years have seen an upsurge in studies investigating the role of lipids in +RNA virus replication, in particular of sterols, and uncovered that membrane contact sites and lipid transfer proteins are hijacked by viruses and play pivotal roles in VRC formation.",

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Viral rewiring of cellular lipid metabolism to create membranous replication compartments

Abstract

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