Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

H. Kalra; R.J. Simpson; H. Ji; E. Aikawa; P. Altevogt; P. Askenase; V.C. Bond; F.E. Borras; X. Breakefield; V. Budnik; E. Buzas; G. Camussi; A. Clayton; E. Cocucci; J.M. Falcon-Perez; S. Gabrielsson; Y.S. Gho; D. Gupta; H.C. Harsha; A. Hendrix; A.F. Hill; J.M. Inal; G. Jenster; E.M. Kramer-Albers; S.K. Lim; A. Llorente; J. Lotvall; A. Marcilla; L. Mincheva-Nilsson; I. Nazarenko; R. Nieuwland; E.N.M. Nolte-'t Hoen; A Pandey; T. Patel; M.G. Piper; S. Pluchino; T.S. Prasad; L. Rajendran; G. Raposo; M. Record; G.E. Reid; F. Sanchez-Madrid; R.M. Schiffelers; P. Siljander; A. Stensballe; W. Stoorvogel; D. Taylor; C. Thery; H. Valadi; B.W.M. van Balkom; J. Vazquez; M. Vidal; M.H.M. Wauben; M. Yanez-Mo; M. Zoeller; S. Mathivanan

doi:10.1371/journal.pbio.1001450

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

H. Kalra, R.J. Simpson, H. Ji, E. Aikawa, P. Altevogt, P. Askenase, V.C. Bond, F.E. Borras, X. Breakefield, V. Budnik, E. Buzas, G. Camussi, A. Clayton, E. Cocucci, J.M. Falcon-Perez, S. Gabrielsson, Y.S. Gho, D. Gupta, H.C. Harsha, A. HendrixA.F. Hill, J.M. Inal, G. Jenster, E.M. Kramer-Albers, S.K. Lim, A. Llorente, J. Lotvall, A. Marcilla, L. Mincheva-Nilsson, I. Nazarenko, R. Nieuwland, E.N.M. Nolte-'t Hoen, A Pandey, T. Patel, M.G. Piper, S. Pluchino, T.S. Prasad, L. Rajendran, G. Raposo, M. Record, G.E. Reid, F. Sanchez-Madrid, R.M. Schiffelers, P. Siljander, A. Stensballe, W. Stoorvogel, D. Taylor, C. Thery, H. Valadi, B.W.M. van Balkom, J. Vazquez, M. Vidal, M.H.M. Wauben, M. Yanez-Mo, M. Zoeller, S. Mathivanan

Sub Atmospheric physics and chemistry

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	PloS Biology [E]
Volume	10
Issue number	12
DOIs	https://doi.org/10.1371/journal.pbio.1001450
Publication status	Published - 2012

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10.1371/journal.pbio.1001450

Vesiclepedia a compendium for extracellular vesicles with continuous community annotation
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Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borras, F. E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J. M., Gabrielsson, S., Gho, Y. S., Gupta, D., Harsha, H. C., ... Mathivanan, S. (2012). Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. PloS Biology [E], 10(12), 1-5. https://doi.org/10.1371/journal.pbio.1001450

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title = "Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation",

abstract = "Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.",

author = "H. Kalra and R.J. Simpson and H. Ji and E. Aikawa and P. Altevogt and P. Askenase and V.C. Bond and F.E. Borras and X. Breakefield and V. Budnik and E. Buzas and G. Camussi and A. Clayton and E. Cocucci and J.M. Falcon-Perez and S. Gabrielsson and Y.S. Gho and D. Gupta and H.C. Harsha and A. Hendrix and A.F. Hill and J.M. Inal and G. Jenster and E.M. Kramer-Albers and S.K. Lim and A. Llorente and J. Lotvall and A. Marcilla and L. Mincheva-Nilsson and I. Nazarenko and R. Nieuwland and {Nolte-'t Hoen}, E.N.M. and A Pandey and T. Patel and M.G. Piper and S. Pluchino and T.S. Prasad and L. Rajendran and G. Raposo and M. Record and G.E. Reid and F. Sanchez-Madrid and R.M. Schiffelers and P. Siljander and A. Stensballe and W. Stoorvogel and D. Taylor and C. Thery and H. Valadi and {van Balkom}, B.W.M. and J. Vazquez and M. Vidal and M.H.M. Wauben and M. Yanez-Mo and M. Zoeller and S. Mathivanan",

year = "2012",

doi = "10.1371/journal.pbio.1001450",

language = "English",

volume = "10",

pages = "1--5",

journal = "PloS Biology [E]",

issn = "1544-9173",

publisher = "Public Library of Science",

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Kalra, H, Simpson, RJ, Ji, H, Aikawa, E, Altevogt, P, Askenase, P, Bond, VC, Borras, FE, Breakefield, X, Budnik, V, Buzas, E, Camussi, G, Clayton, A, Cocucci, E, Falcon-Perez, JM, Gabrielsson, S, Gho, YS, Gupta, D, Harsha, HC, Hendrix, A, Hill, AF, Inal, JM, Jenster, G, Kramer-Albers, EM, Lim, SK, Llorente, A, Lotvall, J, Marcilla, A, Mincheva-Nilsson, L, Nazarenko, I, Nieuwland, R, Nolte-'t Hoen, ENM, Pandey, A, Patel, T, Piper, MG, Pluchino, S, Prasad, TS, Rajendran, L, Raposo, G, Record, M, Reid, GE, Sanchez-Madrid, F, Schiffelers, RM, Siljander, P, Stensballe, A, Stoorvogel, W, Taylor, D, Thery, C, Valadi, H, van Balkom, BWM, Vazquez, J, Vidal, M, Wauben, MHM, Yanez-Mo, M, Zoeller, M & Mathivanan, S 2012, 'Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation', PloS Biology [E], vol. 10, no. 12, pp. 1-5. https://doi.org/10.1371/journal.pbio.1001450

TY - JOUR

T1 - Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

AU - Kalra, H.

AU - Simpson, R.J.

AU - Ji, H.

AU - Aikawa, E.

AU - Altevogt, P.

AU - Askenase, P.

AU - Bond, V.C.

AU - Borras, F.E.

AU - Breakefield, X.

AU - Budnik, V.

AU - Buzas, E.

AU - Camussi, G.

AU - Clayton, A.

AU - Cocucci, E.

AU - Falcon-Perez, J.M.

AU - Gabrielsson, S.

AU - Gho, Y.S.

AU - Gupta, D.

AU - Harsha, H.C.

AU - Hendrix, A.

AU - Hill, A.F.

AU - Inal, J.M.

AU - Jenster, G.

AU - Kramer-Albers, E.M.

AU - Lim, S.K.

AU - Llorente, A.

AU - Lotvall, J.

AU - Marcilla, A.

AU - Mincheva-Nilsson, L.

AU - Nazarenko, I.

AU - Nieuwland, R.

AU - Nolte-'t Hoen, E.N.M.

AU - Pandey, A

AU - Patel, T.

AU - Piper, M.G.

AU - Pluchino, S.

AU - Prasad, T.S.

AU - Rajendran, L.

AU - Raposo, G.

AU - Record, M.

AU - Reid, G.E.

AU - Sanchez-Madrid, F.

AU - Schiffelers, R.M.

AU - Siljander, P.

AU - Stensballe, A.

AU - Stoorvogel, W.

AU - Taylor, D.

AU - Thery, C.

AU - Valadi, H.

AU - van Balkom, B.W.M.

AU - Vazquez, J.

AU - Vidal, M.

AU - Wauben, M.H.M.

AU - Yanez-Mo, M.

AU - Zoeller, M.

AU - Mathivanan, S.

PY - 2012

Y1 - 2012

N2 - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

AB - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

U2 - 10.1371/journal.pbio.1001450

DO - 10.1371/journal.pbio.1001450

M3 - Article

SN - 1544-9173

VL - 10

SP - 1

EP - 5

JO - PloS Biology [E]

JF - PloS Biology [E]

IS - 12

ER -

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

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