VACCINE

Petronella Bos, Martine; Jan Poolman; Boris Tefsen; Maria Tommassen, Johannes, Petrus

VACCINE

Petronella Bos, Martine (Inventor)
, Jan Poolman (Inventor)
, Boris Tefsen (Inventor)
, Maria Tommassen, Johannes, Petrus (Inventor)

Sub Molecular Microbiology

GLAXOSMITHKLINE BIOLOGICALS S.A

Research output: Patent › Academic

Abstract

The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.

Original language	English
Patent number	WO2005064021
IPC	A61K 39/ 00 A N
Priority date	22/07/04
Publication status	Published - 14 Jul 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "VACCINE",

abstract = "The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.",

author = "\{Bos, Martine\}, Petronella and Jan Poolman and Boris Tefsen and \{Tommassen, Johannes, Petrus\}, Maria",

year = "2005",

month = jul,

day = "14",

language = "English",

type = "Patent",

note = "WO2005064021; A61K 39/ 00 A N",

}

TY - PAT

T1 - VACCINE

AU - Bos, Martine, Petronella

AU - Poolman, Jan

AU - Tefsen, Boris

AU - Tommassen, Johannes, Petrus, Maria

PY - 2005/7/14

Y1 - 2005/7/14

N2 - The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.

AB - The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.

M3 - Patent

M1 - WO2005064021

ER -

VACCINE

Abstract

UN SDGs

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