Vaccination of chickens against Campylobacter (review)

M.R. de Zoete, J.P.M. van Putten, J.A. Wagenaar

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The gram-negative bacterium Campylobacter is the leading cause of bacterial entero-colitis in humans and is associated with the occurrence of life-threatening auto-immune based neurological disorders. Chickens, which are often heavily colonized with Campylobacter without signs of pathology, are considered the most important source for human infection. Although vaccination is a well established and effective method to combat various microbes in poultry, a commercial vaccine against Campylobacter has not yet been developed. For the development of such a vaccine, three main challenges can be identified: (1) the identification of novel cross-protection-inducing antigens, (2) the induction of a rapid, potent immune response, and (3) the development of novel adjuvants to further stimulate immunity against Campylobacter. The rapidly emerging knowledge of the biology of Campylobacter in combination with the recent advances in the fields of molecular vaccinology and immunology provide the required setting for the development of an effective vaccine against Campylobacter in poultry.
    Original languageEnglish
    Pages (from-to)5548-5557
    Number of pages10
    JournalVaccine
    Volume25
    Issue number30
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Campylobacter
    • Vaccine
    • Chicken

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