Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0

A. M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G. A. Burton; M. A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M. L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A. D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D. L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T. M. Penning; A. H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T. W. Schultz; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar

doi:10.1016/j.fct.2025.115755

Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0

A. M. Api
, A. Bartlett
, D. Belsito
, D. Botelho
, M. Bruze
, A. Bryant-Friedrich
, G. A. Burton
, M. A. Cancellieri
, H. Chon
, M. Cronin
, S. Crotty
, M. L. Dagli
, W. Dekant
, C. Deodhar
, K. Farrell
, A. D. Fryer
, L. Jones
, K. Joshi
, A. Lapczynski
, D. L. Laskin

M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T. M. Penning, A. H. Piersma, G. Ritacco, N. Sadekar, I. Schember, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan^*, Y. Thakkar

^*Corresponding author for this work

Research Institute for Fragrance Materials Inc.
Columbia University
Lund University
Wayne State University
University of Michigan, Ann Arbor
Liverpool John Moores University
Universidade de São Paulo
University of Würzburg
Oregon Health and Science University
Rutgers - The State University of New Jersey, New Brunswick
University of Pennsylvania
University of Arizona

Research output: Contribution to journal › Review article › peer-review

Abstract

• Nonanoic acid; a safety assessment based on RIFM's criteria. •A safety assessment based on 7 human health endpoints plus environmental. •All endpoints were cleared using target data, read-across, and/or TTC.

Original language	English
Article number	115755
Number of pages	10
Journal	Food and Chemical Toxicology
Volume	206
Issue number	Suppl. 1
Early online date	23 Sept 2025
DOIs	https://doi.org/10.1016/j.fct.2025.115755
Publication status	Published - Dec 2025

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.fct.2025.115755

Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0Final published version, 2.46 MBLicence: Taverne

Cite this

Api, A. M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G. A., Cancellieri, M. A., Chon, H., Cronin, M., Crotty, S., Dagli, M. L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A. D., Jones, L., Joshi, K., Lapczynski, A., ... Thakkar, Y. (2025). Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0. Food and Chemical Toxicology, 206(Suppl. 1), Article 115755. https://doi.org/10.1016/j.fct.2025.115755

@article{4ca8d732a7b34610945d86da06ec5e0e,

title = "Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0",

abstract = "• Nonanoic acid; a safety assessment based on RIFM's criteria. •A safety assessment based on 7 human health endpoints plus environmental. •All endpoints were cleared using target data, read-across, and/or TTC.",

author = "Api, \{A. M.\} and A. Bartlett and D. Belsito and D. Botelho and M. Bruze and A. Bryant-Friedrich and Burton, \{G. A.\} and Cancellieri, \{M. A.\} and H. Chon and M. Cronin and S. Crotty and Dagli, \{M. L.\} and W. Dekant and C. Deodhar and K. Farrell and Fryer, \{A. D.\} and L. Jones and K. Joshi and A. Lapczynski and Laskin, \{D. L.\} and M. Lavelle and I. Lee and H. Moustakas and J. Muldoon and Penning, \{T. M.\} and Piersma, \{A. H.\} and G. Ritacco and N. Sadekar and I. Schember and Schultz, \{T. W.\} and F. Siddiqi and Sipes, \{I. G.\} and G. Sullivan and Y. Thakkar",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

year = "2025",

month = dec,

doi = "10.1016/j.fct.2025.115755",

language = "English",

volume = "206",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

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number = "Suppl. 1",

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Api, AM, Bartlett, A, Belsito, D, Botelho, D, Bruze, M, Bryant-Friedrich, A, Burton, GA, Cancellieri, MA, Chon, H, Cronin, M, Crotty, S, Dagli, ML, Dekant, W, Deodhar, C, Farrell, K, Fryer, AD, Jones, L, Joshi, K, Lapczynski, A, Laskin, DL, Lavelle, M, Lee, I, Moustakas, H, Muldoon, J, Penning, TM, Piersma, AH, Ritacco, G, Sadekar, N, Schember, I, Schultz, TW, Siddiqi, F, Sipes, IG, Sullivan, G & Thakkar, Y 2025, 'Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0', Food and Chemical Toxicology, vol. 206, no. Suppl. 1, 115755. https://doi.org/10.1016/j.fct.2025.115755

TY - JOUR

T1 - Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0

AU - Api, A. M.

AU - Bartlett, A.

AU - Belsito, D.

AU - Botelho, D.

AU - Bruze, M.

AU - Bryant-Friedrich, A.

AU - Burton, G. A.

AU - Cancellieri, M. A.

AU - Chon, H.

AU - Cronin, M.

AU - Crotty, S.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Deodhar, C.

AU - Farrell, K.

AU - Fryer, A. D.

AU - Jones, L.

AU - Joshi, K.

AU - Lapczynski, A.

AU - Laskin, D. L.

AU - Lavelle, M.

AU - Lee, I.

AU - Moustakas, H.

AU - Muldoon, J.

AU - Penning, T. M.

AU - Piersma, A. H.

AU - Ritacco, G.

AU - Sadekar, N.

AU - Schember, I.

AU - Schultz, T. W.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

PY - 2025/12

Y1 - 2025/12

N2 - • Nonanoic acid; a safety assessment based on RIFM's criteria. •A safety assessment based on 7 human health endpoints plus environmental. •All endpoints were cleared using target data, read-across, and/or TTC.

AB - • Nonanoic acid; a safety assessment based on RIFM's criteria. •A safety assessment based on 7 human health endpoints plus environmental. •All endpoints were cleared using target data, read-across, and/or TTC.

UR - https://www.scopus.com/pages/publications/105019207326

U2 - 10.1016/j.fct.2025.115755

DO - 10.1016/j.fct.2025.115755

M3 - Review article

C2 - 40998084

AN - SCOPUS:105019207326

SN - 0278-6915

VL - 206

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - Suppl. 1

M1 - 115755

ER -

Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0

Abstract

Bibliographical note

UN SDGs

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