Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0

A. M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G. A. Burton; M. A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M. L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A. D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D. L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T. M. Penning; A. H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T. W. Schultz; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar

doi:10.1016/j.fct.2025.115750

Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0

A. M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Friedrich, G. A. Burton, M. A. Cancellieri, H. Chon, M. Cronin, S. Crotty, M. L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A. D. Fryer, L. Jones, K. Joshi, A. Lapczynski, D. L. LaskinM. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T. M. Penning, A. H. Piersma, G. Ritacco, N. Sadekar, I. Schember, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan^*, Y. Thakkar

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

•2-Methyl-4-phenyl-1,3-dioxolane; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

Original language	English
Article number	115750
Journal	Food and Chemical Toxicology
Volume	206
DOIs	https://doi.org/10.1016/j.fct.2025.115750
Publication status	Published - Dec 2025

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2025.115750

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Api, A. M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G. A., Cancellieri, M. A., Chon, H., Cronin, M., Crotty, S., Dagli, M. L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A. D., Jones, L., Joshi, K., Lapczynski, A., ... Thakkar, Y. (2025). Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0. Food and Chemical Toxicology, 206, Article 115750. https://doi.org/10.1016/j.fct.2025.115750

@article{78f99f73e27f4791a36c3bdc126a3b34,

title = "Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0",

abstract = "•2-Methyl-4-phenyl-1,3-dioxolane; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.",

author = "Api, \{A. M.\} and A. Bartlett and D. Belsito and D. Botelho and M. Bruze and A. Bryant-Friedrich and Burton, \{G. A.\} and Cancellieri, \{M. A.\} and H. Chon and M. Cronin and S. Crotty and Dagli, \{M. L.\} and W. Dekant and C. Deodhar and K. Farrell and Fryer, \{A. D.\} and L. Jones and K. Joshi and A. Lapczynski and Laskin, \{D. L.\} and M. Lavelle and I. Lee and H. Moustakas and J. Muldoon and Penning, \{T. M.\} and Piersma, \{A. H.\} and G. Ritacco and N. Sadekar and I. Schember and Schultz, \{T. W.\} and F. Siddiqi and Sipes, \{I. G.\} and G. Sullivan and Y. Thakkar",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

year = "2025",

month = dec,

doi = "10.1016/j.fct.2025.115750",

language = "English",

volume = "206",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Ltd",

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Api, AM, Bartlett, A, Belsito, D, Botelho, D, Bruze, M, Bryant-Friedrich, A, Burton, GA, Cancellieri, MA, Chon, H, Cronin, M, Crotty, S, Dagli, ML, Dekant, W, Deodhar, C, Farrell, K, Fryer, AD, Jones, L, Joshi, K, Lapczynski, A, Laskin, DL, Lavelle, M, Lee, I, Moustakas, H, Muldoon, J, Penning, TM, Piersma, AH, Ritacco, G, Sadekar, N, Schember, I, Schultz, TW, Siddiqi, F, Sipes, IG, Sullivan, G & Thakkar, Y 2025, 'Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0', Food and Chemical Toxicology, vol. 206, 115750. https://doi.org/10.1016/j.fct.2025.115750

TY - JOUR

T1 - Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0

AU - Api, A. M.

AU - Bartlett, A.

AU - Belsito, D.

AU - Botelho, D.

AU - Bruze, M.

AU - Bryant-Friedrich, A.

AU - Burton, G. A.

AU - Cancellieri, M. A.

AU - Chon, H.

AU - Cronin, M.

AU - Crotty, S.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Deodhar, C.

AU - Farrell, K.

AU - Fryer, A. D.

AU - Jones, L.

AU - Joshi, K.

AU - Lapczynski, A.

AU - Laskin, D. L.

AU - Lavelle, M.

AU - Lee, I.

AU - Moustakas, H.

AU - Muldoon, J.

AU - Penning, T. M.

AU - Piersma, A. H.

AU - Ritacco, G.

AU - Sadekar, N.

AU - Schember, I.

AU - Schultz, T. W.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

PY - 2025/12

Y1 - 2025/12

N2 - •2-Methyl-4-phenyl-1,3-dioxolane; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

AB - •2-Methyl-4-phenyl-1,3-dioxolane; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

UR - https://www.scopus.com/pages/publications/105017960209

U2 - 10.1016/j.fct.2025.115750

DO - 10.1016/j.fct.2025.115750

M3 - Short survey

C2 - 40992723

AN - SCOPUS:105017960209

SN - 0278-6915

VL - 206

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 115750

ER -

Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0

Abstract

Bibliographical note

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