TY - JOUR
T1 - Update to RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4
AU - Api, A. M.
AU - Bartlett, A.
AU - Belsito, D.
AU - Botelho, D.
AU - Bruze, M.
AU - Bryant-Friedrich, A.
AU - Burton, G. A.
AU - Cancellieri, M. A.
AU - Chon, H.
AU - Cronin, M.
AU - Crotty, S.
AU - Dagli, M. L.
AU - Dekant, W.
AU - Deodhar, C.
AU - Farrell, K.
AU - Fryer, A. D.
AU - Jones, L.
AU - Joshi, K.
AU - Lapczynski, A.
AU - Laskin, D. L.
AU - Lavelle, M.
AU - Lee, I.
AU - Moustakas, H.
AU - Muldoon, J.
AU - Penning, T. M.
AU - Piersma, A. H.
AU - Ritacco, G.
AU - Sadekar, N.
AU - Schember, I.
AU - Schultz, T. W.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/7
Y1 - 2025/7
N2 - 1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1,1-diethoxyheptane is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1,1-diethoxyheptane is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 1,1-diethoxyheptane was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
AB - 1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1,1-diethoxyheptane is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1,1-diethoxyheptane is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 1,1-diethoxyheptane was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
UR - http://www.scopus.com/inward/record.url?scp=105003746703&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2025.115470
DO - 10.1016/j.fct.2025.115470
M3 - Short survey
AN - SCOPUS:105003746703
SN - 0278-6915
VL - 201
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - Suppl. 1
M1 - 115470
ER -