Abstract
The results obtained in chapter 2-5 of this thesis demonstrate that
the amino acid sequence of the spike in combination with the presence of N-glycans on the
spike affect binding to receptors and host cells (chapter 3 and 4), and might lead towards
an altered tissue tropism in vivo. In particular, our studies on the glycan receptor specificity
and affinity of three AvCoV pathotypes (chapters 2, 4 and 5) revealed both novel glycan
receptors (chapter 5) and yet unidentified ligands used by avian coronaviruses (chapter 2
and 4). Such identification of virus-host interactions can significantly improve targeted and
rational design of broadly neutralizing antibodies and/or vaccination strategies which can
be of aid to combat these important viruses in poultry.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 1 Sept 2020 |
Place of Publication | Utrecht |
Publisher | |
Print ISBNs | 978-90-373-7308-8 |
DOIs | |
Publication status | Published - 1 Sept 2020 |
Keywords
- avian coronaviruses
- virus-host interactions