Unravelling virus-host interactions of avian coronaviruses

Kimberley Mariëlle Bouwman

Research output: ThesisDoctoral thesis 1 (Research UU / Graduation UU)

Abstract

The results obtained in chapter 2-5 of this thesis demonstrate that the amino acid sequence of the spike in combination with the presence of N-glycans on the spike affect binding to receptors and host cells (chapter 3 and 4), and might lead towards an altered tissue tropism in vivo. In particular, our studies on the glycan receptor specificity and affinity of three AvCoV pathotypes (chapters 2, 4 and 5) revealed both novel glycan receptors (chapter 5) and yet unidentified ligands used by avian coronaviruses (chapter 2 and 4). Such identification of virus-host interactions can significantly improve targeted and rational design of broadly neutralizing antibodies and/or vaccination strategies which can be of aid to combat these important viruses in poultry.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Utrecht University
Supervisors/Advisors
  • Gröne, Andrea, Primary supervisor
  • Verheije, Hélène, Co-supervisor
  • de Vries, Robert, Co-supervisor
Award date1 Sept 2020
Place of PublicationUtrecht
Publisher
Print ISBNs978-90-373-7308-8
DOIs
Publication statusPublished - 1 Sept 2020

Keywords

  • avian coronaviruses
  • virus-host interactions

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