Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Charis Rousou, Carl C L Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers

Research output: Contribution to journalReview articlepeer-review

Abstract

The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood-retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed.

Original languageEnglish
Article number1782
Pages (from-to)1-35
JournalPharmaceutics
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • ultrasound
  • microbubble
  • drug delivery
  • blood–retina barrier
  • ocular drug delivery
  • USMB
  • cellular drug delivery

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