Two clinical trials: surgery in cows

Research output: Contribution to conferenceAbstractAcademic


Societal concerns on antibiotic resistance urged us to evaluate
the use of prophylactic and postoperative antibiotic treatments
for caesarean section (CS) and exploratory laparotomy (LA) in
the teaching hospital. To this end, we conducted a randomized
prospective trial for both abdominal surgeries. Cows submitted
for CS received either a prophylaxis with 5 gram of ampicillin-
sodium IV only (CSL) or in combination with post-operative
IM injections of ampicillin-trihydrate 20% for three days (10 mg/
kg, 2 dd)(CSH). Cows that underwent LA were given no antibiotic
prophylaxis (LAN) or 5 gram of ampicillin-sodium IV (LAL).
Cows in all groups were found healthy after a follow-up period
of 10 days given their normal temperature, feed intake and clinical
appearance. More antibiotic treatments were needed for
the treatment of complications for CS compared to LA groups,
but did not differ within surgery type between protocols. We observed
that CSL cows required more treatments for diseases
that were not related to the surgery than CSH cows (OR 2.8 (CI
1.2-7.2)). The percentage of infected sutures was higher for
LAN cows compared to LAL cows (OR 2.6 (CI 1.5-4.9). We estimated
that 29 CSH treatments are needed to prevent 1 CS
cow with serious complications related to the surgery in the
CSL group. Likewise, 53 LAL treatments would prevent 1 LA
cow with complications related to the surgery in the LAN group.
We therefore concluded that it is possible to reduce antibiotic
prophylaxis in CS and LA cows. The low number of clinically
detected complications could effectively be treated by postoperative
Original languageEnglish
Publication statusPublished - 28 Aug 2018
EventWorld Buiatrics Congress 2018 Sapporo Japan - Sapporo, Japan
Duration: 28 Aug 20181 Sept 2018


ConferenceWorld Buiatrics Congress 2018 Sapporo Japan
Internet address


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