TY - JOUR
T1 - Twist-Bend Coupling and the Torsional Response of Double-Stranded DNA
AU - Nomidis, Stefanos K.
AU - Kriegel, Franziska
AU - Vanderlinden, Willem
AU - Lipfert, Jan
AU - Carlon, Enrico
PY - 2017/5/26
Y1 - 2017/5/26
N2 - Recent magnetic tweezers experiments have reported systematic deviations of the twist response of double-stranded DNA from the predictions of the twistable wormlike chain model. Here we show, by means of analytical results and computer simulations, that these discrepancies can be resolved if a coupling between twist and bend is introduced. We obtain an estimate of 40±10 nm for the twist-bend coupling constant. Our simulations are in good agreement with high-resolution, magnetic-tweezers torque data. Although the existence of twist-bend coupling was predicted long ago [J. Marko and E. Siggia, Macromolecules 27, 981 (1994)MAMOBX0024-929710.1021/ma00082a015], its effects on the mechanical properties of DNA have been so far largely unexplored. We expect that this coupling plays an important role in several aspects of DNA statics and dynamics.
AB - Recent magnetic tweezers experiments have reported systematic deviations of the twist response of double-stranded DNA from the predictions of the twistable wormlike chain model. Here we show, by means of analytical results and computer simulations, that these discrepancies can be resolved if a coupling between twist and bend is introduced. We obtain an estimate of 40±10 nm for the twist-bend coupling constant. Our simulations are in good agreement with high-resolution, magnetic-tweezers torque data. Although the existence of twist-bend coupling was predicted long ago [J. Marko and E. Siggia, Macromolecules 27, 981 (1994)MAMOBX0024-929710.1021/ma00082a015], its effects on the mechanical properties of DNA have been so far largely unexplored. We expect that this coupling plays an important role in several aspects of DNA statics and dynamics.
UR - https://www.mendeley.com/catalogue/a4472b38-f2c8-35ec-a9f3-0d03e6111e48/
U2 - 10.1103/PhysRevLett.118.217801
DO - 10.1103/PhysRevLett.118.217801
M3 - Article
C2 - 28598642
SN - 0031-9007
VL - 118
JO - Physical Review Letters
JF - Physical Review Letters
IS - 21
ER -