Turnover of Murine Cytomegalovirus-Expanded CD8 T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response.

Mariona Baliu-Piqué, Julia Drylewicz, Xiaoyan Zheng, Lisa Borkner, Arpit C Swain, Sigrid A Otto, Rob J de Boer, Kiki Tesselaar, Luka Cicin-Sain, José A M Borghans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The potential of memory T cells to provide protection against reinfection is beyond question. Yet, it remains debated whether long-term T cell memory is due to long-lived memory cells. There is ample evidence that blood-derived memory phenotype CD8 + T cells maintain themselves through cell division, rather than through longevity of individual cells. It has recently been proposed, however, that there may be heterogeneity in the lifespans of memory T cells, depending on factors such as exposure to cognate Ag. CMV infection induces not only conventional, contracting T cell responses, but also inflationary CD8 + T cell responses, which are maintained at unusually high numbers, and are even thought to continue to expand over time. It has been proposed that such inflating T cell responses result from the accumulation of relatively long-lived CMV-specific memory CD8 + T cells. Using in vivo deuterium labeling and mathematical modeling, we found that the average production rates and expected lifespans of mouse CMV-specific CD8 + T cells are very similar to those of bulk memory-phenotype CD8 + T cells. Even CMV-specific inflationary CD8 + T cell responses that differ 3-fold in size were found to turn over at similar rates.

Original languageEnglish
Pages (from-to)799-806
Number of pages9
JournalJournal of Immunology
Volume208
Issue number4
DOIs
Publication statusPublished - 15 Feb 2022

Bibliographical note

Copyright © 2022 by The American Association of Immunologists, Inc.

Keywords

  • Algorithms
  • Animals
  • Biomarkers
  • CD8-Positive T-Lymphocytes/immunology
  • Cytomegalovirus Infections/immunology
  • Epitopes, T-Lymphocyte/immunology
  • Female
  • Host-Pathogen Interactions/immunology
  • Immunologic Memory
  • Immunophenotyping
  • Memory T Cells/immunology
  • Mice
  • Models, Theoretical
  • Muromegalovirus/immunology
  • T-Lymphocyte Subsets/immunology

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