Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

J.Y.Y. Wong; C.A. Hsiung; K. Matsuo; M.P. Wong; W.J. Seow; M. Song; I.-S. Chang; N. Chatterjee; W. Hu; C. Wu; T. Mitsudomi; W. Zheng; J.H. Kim; A. Seow; N.E. Caporaso; M.-H. Shin; L.P. Chung; S.-J. An; H. Zheng; Y. Yatabe; Y.T. Kim; Q. Cai; Y.-C. Kim; B.A. Bassig; J.C.M. Ho; B.-T. Ji; Y. Daigo; H. Ito; Y. Momozawa; K. Ashikawa; Y. Kamatani; T. Honda; H.D. Hosgood; H. Sakamoto; H. Kunitoh; K. Tsuta; S.-I. Watanabe; M. Kubo; Y. Miyagi; H. Nakayama; S. Matsumoto; M. Tsuboi; K. Goto; L. Song; X. Hua; A. Takahashi; A. Goto; Y. Minamiya; K. Shimizu; K. Tanaka; F. Wei; F. Matsuda; Y.H. Kim; I.-J. Oh; F. Song; W.-C. Su; G.-C. Chang; K.-Y. Chen; L.-H. Chien; Y.-B. Xiang; S.-S. Kweon; K.-M. Lee; B. Blechter; B. Qian; D. Lu; H.-S. Jeon; C.-F. Hsiao; J.S. Sung; Y.-H. Tsai; Y.J. Jung; C.C. Chung; L. Burdett; M. Yeager; A. Hutchinson; S.I. Berndt; H. Pang; J.E. Choi; K.H. Park; S.W. Sung; M. Zhu; P. Guan; W. Tan; M. Hsin; K.-Y. Sit; J. Ho; Y.Y. Choi; J.S. Kim; H.I. Yoon; I.K. Park; P. Xu; Q. He; R.-P. Perng; R. Vermeulen; W.-Y. Lim; K.-C. Chen; L. Jin; S.-S. Jiang; T. Yamaji; B. Hicks; K. Wyatt; J. Dai; G. Jin; B. Song; S. Cheng; P. Cui; M. Iwasaki; T. Shimazu; S. Tsugane; K. Fei; G. Wu; H.-C. Lin; Y.-H. Fang; F.-Y. Tsai; W.-S. Hsieh; J. Yu; V.L. Stevens; I.A. Laird-Offringa; C.N. Marconett; L. Rieswijk; A. Chao; X.-O. Shu; D. Lin; K. Chen; B. Zhou; T. Kohno; H. Shen; S.J. Chanock; N. Rothman; Q. Lan

doi:10.1016/j.ygeno.2019.07.008

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

J.Y.Y. Wong, C.A. Hsiung, K. Matsuo, M.P. Wong, W.J. Seow, M. Song, I.-S. Chang, N. Chatterjee, W. Hu, C. Wu, T. Mitsudomi, W. Zheng, J.H. Kim, A. Seow, N.E. Caporaso, M.-H. Shin, L.P. Chung, S.-J. An, H. Zheng, Y. YatabeY.T. Kim, Q. Cai, Y.-C. Kim, B.A. Bassig, J.C.M. Ho, B.-T. Ji, Y. Daigo, H. Ito, Y. Momozawa, K. Ashikawa, Y. Kamatani, T. Honda, H.D. Hosgood, H. Sakamoto, H. Kunitoh, K. Tsuta, S.-I. Watanabe, M. Kubo, Y. Miyagi, H. Nakayama, S. Matsumoto, M. Tsuboi, K. Goto, L. Song, X. Hua, A. Takahashi, A. Goto, Y. Minamiya, K. Shimizu, K. Tanaka, F. Wei, F. Matsuda, Y.H. Kim, I.-J. Oh, F. Song, W.-C. Su, G.-C. Chang, K.-Y. Chen, L.-H. Chien, Y.-B. Xiang, S.-S. Kweon, K.-M. Lee, B. Blechter, B. Qian, D. Lu, H.-S. Jeon, C.-F. Hsiao, J.S. Sung, Y.-H. Tsai, Y.J. Jung, C.C. Chung, L. Burdett, M. Yeager, A. Hutchinson, S.I. Berndt, H. Pang, J.E. Choi, K.H. Park, S.W. Sung, M. Zhu, P. Guan, W. Tan, M. Hsin, K.-Y. Sit, J. Ho, Y.Y. Choi, J.S. Kim, H.I. Yoon, I.K. Park, P. Xu, Q. He, R.-P. Perng, R. Vermeulen, W.-Y. Lim, K.-C. Chen, L. Jin, S.-S. Jiang, T. Yamaji, B. Hicks, K. Wyatt, J. Dai, G. Jin, B. Song, S. Cheng, P. Cui, M. Iwasaki, T. Shimazu, S. Tsugane, K. Fei, G. Wu, H.-C. Lin, Y.-H. Fang, F.-Y. Tsai, W.-S. Hsieh, J. Yu, V.L. Stevens, I.A. Laird-Offringa, C.N. Marconett, L. Rieswijk, A. Chao, X.-O. Shu, D. Lin, K. Chen, B. Zhou, T. Kohno, H. Shen, S.J. Chanock, N. Rothman, Q. Lan

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

Original language	English
Pages (from-to)	1223-1232
Number of pages	10
Journal	Genomics
Volume	112
Issue number	2
DOIs	https://doi.org/10.1016/j.ygeno.2019.07.008
Publication status	Published - Mar 2020

Keywords

Tuberculosis
Lung cancer
Lung adenocarcinoma
Mendelian randomization
Pathway analysis

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10.1016/j.ygeno.2019.07.008

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Wong, J. Y. Y., Hsiung, C. A., Matsuo, K., Wong, M. P., Seow, W. J., Song, M., Chang, I.-S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J. H., Seow, A., Caporaso, N. E., Shin, M.-H., Chung, L. P., An, S.-J., Zheng, H., ... Lan, Q. (2020). Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women. Genomics, 112(2), 1223-1232. https://doi.org/10.1016/j.ygeno.2019.07.008

@article{1b8db3553732449d80225878d0ade329,

title = "Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women",

abstract = "We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.",

keywords = "Tuberculosis, Lung cancer, Lung adenocarcinoma, Mendelian randomization, Pathway analysis",

author = "J.Y.Y. Wong and C.A. Hsiung and K. Matsuo and M.P. Wong and W.J. Seow and M. Song and I.-S. Chang and N. Chatterjee and W. Hu and C. Wu and T. Mitsudomi and W. Zheng and J.H. Kim and A. Seow and N.E. Caporaso and M.-H. Shin and L.P. Chung and S.-J. An and H. Zheng and Y. Yatabe and Y.T. Kim and Q. Cai and Y.-C. Kim and B.A. Bassig and J.C.M. Ho and B.-T. Ji and Y. Daigo and H. Ito and Y. Momozawa and K. Ashikawa and Y. Kamatani and T. Honda and H.D. Hosgood and H. Sakamoto and H. Kunitoh and K. Tsuta and S.-I. Watanabe and M. Kubo and Y. Miyagi and H. Nakayama and S. Matsumoto and M. Tsuboi and K. Goto and L. Song and X. Hua and A. Takahashi and A. Goto and Y. Minamiya and K. Shimizu and K. Tanaka and F. Wei and F. Matsuda and Y.H. Kim and I.-J. Oh and F. Song and W.-C. Su and G.-C. Chang and K.-Y. Chen and L.-H. Chien and Y.-B. Xiang and S.-S. Kweon and K.-M. Lee and B. Blechter and B. Qian and D. Lu and H.-S. Jeon and C.-F. Hsiao and J.S. Sung and Y.-H. Tsai and Y.J. Jung and C.C. Chung and L. Burdett and M. Yeager and A. Hutchinson and S.I. Berndt and H. Pang and J.E. Choi and K.H. Park and S.W. Sung and M. Zhu and P. Guan and W. Tan and M. Hsin and K.-Y. Sit and J. Ho and Y.Y. Choi and J.S. Kim and H.I. Yoon and I.K. Park and P. Xu and Q. He and R.-P. Perng and R. Vermeulen and W.-Y. Lim and K.-C. Chen and L. Jin and S.-S. Jiang and T. Yamaji and B. Hicks and K. Wyatt and J. Dai and G. Jin and B. Song and S. Cheng and P. Cui and M. Iwasaki and T. Shimazu and S. Tsugane and K. Fei and G. Wu and H.-C. Lin and Y.-H. Fang and F.-Y. Tsai and W.-S. Hsieh and J. Yu and V.L. Stevens and I.A. Laird-Offringa and C.N. Marconett and L. Rieswijk and A. Chao and X.-O. Shu and D. Lin and K. Chen and B. Zhou and T. Kohno and H. Shen and S.J. Chanock and N. Rothman and Q. Lan",

note = "Cited By :3 Export Date: 8 December 2021",

year = "2020",

month = mar,

doi = "10.1016/j.ygeno.2019.07.008",

language = "English",

volume = "112",

pages = "1223--1232",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "2",

}

Wong, JYY, Hsiung, CA, Matsuo, K, Wong, MP, Seow, WJ, Song, M, Chang, I-S, Chatterjee, N, Hu, W, Wu, C, Mitsudomi, T, Zheng, W, Kim, JH, Seow, A, Caporaso, NE, Shin, M-H, Chung, LP, An, S-J, Zheng, H, Yatabe, Y, Kim, YT, Cai, Q, Kim, Y-C, Bassig, BA, Ho, JCM, Ji, B-T, Daigo, Y, Ito, H, Momozawa, Y, Ashikawa, K, Kamatani, Y, Honda, T, Hosgood, HD, Sakamoto, H, Kunitoh, H, Tsuta, K, Watanabe, S-I, Kubo, M, Miyagi, Y, Nakayama, H, Matsumoto, S, Tsuboi, M, Goto, K, Song, L, Hua, X, Takahashi, A, Goto, A, Minamiya, Y, Shimizu, K, Tanaka, K, Wei, F, Matsuda, F, Kim, YH, Oh, I-J, Song, F, Su, W-C, Chang, G-C, Chen, K-Y, Chien, L-H, Xiang, Y-B, Kweon, S-S, Lee, K-M, Blechter, B, Qian, B, Lu, D, Jeon, H-S, Hsiao, C-F, Sung, JS, Tsai, Y-H, Jung, YJ, Chung, CC, Burdett, L, Yeager, M, Hutchinson, A, Berndt, SI, Pang, H, Choi, JE, Park, KH, Sung, SW, Zhu, M, Guan, P, Tan, W, Hsin, M, Sit, K-Y, Ho, J, Choi, YY, Kim, JS, Yoon, HI, Park, IK, Xu, P, He, Q, Perng, R-P, Vermeulen, R, Lim, W-Y, Chen, K-C, Jin, L, Jiang, S-S, Yamaji, T, Hicks, B, Wyatt, K, Dai, J, Jin, G, Song, B, Cheng, S, Cui, P, Iwasaki, M, Shimazu, T, Tsugane, S, Fei, K, Wu, G, Lin, H-C, Fang, Y-H, Tsai, F-Y, Hsieh, W-S, Yu, J, Stevens, VL, Laird-Offringa, IA, Marconett, CN, Rieswijk, L, Chao, A, Shu, X-O, Lin, D, Chen, K, Zhou, B, Kohno, T, Shen, H, Chanock, SJ, Rothman, N & Lan, Q 2020, 'Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women', Genomics, vol. 112, no. 2, pp. 1223-1232. https://doi.org/10.1016/j.ygeno.2019.07.008

TY - JOUR

T1 - Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

AU - Wong, J.Y.Y.

AU - Hsiung, C.A.

AU - Matsuo, K.

AU - Wong, M.P.

AU - Seow, W.J.

AU - Song, M.

AU - Chang, I.-S.

AU - Chatterjee, N.

AU - Hu, W.

AU - Wu, C.

AU - Mitsudomi, T.

AU - Zheng, W.

AU - Kim, J.H.

AU - Seow, A.

AU - Caporaso, N.E.

AU - Shin, M.-H.

AU - Chung, L.P.

AU - An, S.-J.

AU - Zheng, H.

AU - Yatabe, Y.

AU - Kim, Y.T.

AU - Cai, Q.

AU - Kim, Y.-C.

AU - Bassig, B.A.

AU - Ho, J.C.M.

AU - Ji, B.-T.

AU - Daigo, Y.

AU - Ito, H.

AU - Momozawa, Y.

AU - Ashikawa, K.

AU - Kamatani, Y.

AU - Honda, T.

AU - Hosgood, H.D.

AU - Sakamoto, H.

AU - Kunitoh, H.

AU - Tsuta, K.

AU - Watanabe, S.-I.

AU - Kubo, M.

AU - Miyagi, Y.

AU - Nakayama, H.

AU - Matsumoto, S.

AU - Tsuboi, M.

AU - Goto, K.

AU - Song, L.

AU - Hua, X.

AU - Takahashi, A.

AU - Goto, A.

AU - Minamiya, Y.

AU - Shimizu, K.

AU - Tanaka, K.

AU - Wei, F.

AU - Matsuda, F.

AU - Kim, Y.H.

AU - Oh, I.-J.

AU - Song, F.

AU - Su, W.-C.

AU - Chang, G.-C.

AU - Chen, K.-Y.

AU - Chien, L.-H.

AU - Xiang, Y.-B.

AU - Kweon, S.-S.

AU - Lee, K.-M.

AU - Blechter, B.

AU - Qian, B.

AU - Lu, D.

AU - Jeon, H.-S.

AU - Hsiao, C.-F.

AU - Sung, J.S.

AU - Tsai, Y.-H.

AU - Jung, Y.J.

AU - Chung, C.C.

AU - Burdett, L.

AU - Yeager, M.

AU - Hutchinson, A.

AU - Berndt, S.I.

AU - Pang, H.

AU - Choi, J.E.

AU - Park, K.H.

AU - Sung, S.W.

AU - Zhu, M.

AU - Guan, P.

AU - Tan, W.

AU - Hsin, M.

AU - Sit, K.-Y.

AU - Ho, J.

AU - Choi, Y.Y.

AU - Kim, J.S.

AU - Yoon, H.I.

AU - Park, I.K.

AU - Xu, P.

AU - He, Q.

AU - Perng, R.-P.

AU - Vermeulen, R.

AU - Lim, W.-Y.

AU - Chen, K.-C.

AU - Jin, L.

AU - Jiang, S.-S.

AU - Yamaji, T.

AU - Hicks, B.

AU - Wyatt, K.

AU - Dai, J.

AU - Jin, G.

AU - Song, B.

AU - Cheng, S.

AU - Cui, P.

AU - Iwasaki, M.

AU - Shimazu, T.

AU - Tsugane, S.

AU - Fei, K.

AU - Wu, G.

AU - Lin, H.-C.

AU - Fang, Y.-H.

AU - Tsai, F.-Y.

AU - Hsieh, W.-S.

AU - Yu, J.

AU - Stevens, V.L.

AU - Laird-Offringa, I.A.

AU - Marconett, C.N.

AU - Rieswijk, L.

AU - Chao, A.

AU - Shu, X.-O.

AU - Lin, D.

AU - Chen, K.

AU - Zhou, B.

AU - Kohno, T.

AU - Shen, H.

AU - Chanock, S.J.

AU - Rothman, N.

AU - Lan, Q.

N1 - Cited By :3 Export Date: 8 December 2021

PY - 2020/3

Y1 - 2020/3

N2 - We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

AB - We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

KW - Tuberculosis

KW - Lung cancer

KW - Lung adenocarcinoma

KW - Mendelian randomization

KW - Pathway analysis

UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068966697&doi=10.1016%2fj.ygeno.2019.07.008&partnerID=40&md5=2f03da81363ca97dba6e57d733f19b1b

U2 - 10.1016/j.ygeno.2019.07.008

DO - 10.1016/j.ygeno.2019.07.008

M3 - Article

SN - 0888-7543

VL - 112

SP - 1223

EP - 1232

JO - Genomics

JF - Genomics

IS - 2

ER -

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Keywords

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