Trifluoroacetamido substituted sialyl donors for the preparation of sialyl galactosides

Cristina De Meo, Alexei V. Demchenko, Geert Jan Boons

Research output: Contribution to journalArticleAcademicpeer-review


An efficient method for the direct synthesis of sialyl galactosides was described using glycosyl donor bearing a trifluoroacetamido group. It was found that glycosidation of 5-n-trifluoroacetyle neuraminyl donor with the range of D-galactosyl acceptors gave high yields and α-stereoselectivities for the preparation of Neu5Ac(2,3)Gal derivatives. In the synthesis procedure, mixtures of anomers were obtained. Modest stereoselectivities were also obtained when sialyl donor was glycosidated with the C6 hydroxyl of D-galactosides.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalAustralian Journal of Chemistry
Issue number1-2
Publication statusPublished - 1 Jan 2002
Externally publishedYes


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