Treatment of 46 cats with porcine lente insulin--a prospective, multicentre study

Laurence Michiels, Claudia E Reusch, Andrea Boari, Grant Petrie, Paul Mandigers, Isabelle G Thollot, Dan Rosenberg, Carmel Mooney, Ugo Bonfanti, Artur Font, Andrew Sparkes, Katarina Bewig, Cecile Clercx, Asger L Jensen, Linda J I Horspool

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    This prospective, multicentre, non-blinded, open study followed 46 cats with diabetes mellitus during treatment with porcine lente insulin (also known as porcine insulin zinc suspension, Caninsulin, Intervet) for 16+/-1 weeks (stabilization phase), with additional monitoring of some cats (n=23) for a variable period. At least three of the following were present at initial presentation: appropriate history of clinical signs consistent with diabetes mellitus, glucosuria, blood glucose greater than 15 mmol/l and fructosamine greater than 380 micromol/l. Insulin treatment was started at a dose rate of 0.25-0.5 IU/kg body weight twice daily, with a maximum starting dose of 2 IU/injection. Twenty-eight of the cats were classed as reaching clinical stability during the study, in 23 of these cats this was during the stabilization phase. Seven cats went into remission during the stabilization phase and one of the cats in week 56. Clinical signs of hypoglycaemia, significantly associated with a dose of 3 units or 0.5 IU/kg or more per cat (twice daily), were observed in nine of the 46 cats during the stabilization phase and concomitant biochemical hypoglycaemia was recorded in most cases. Biochemical hypoglycaemia, recorded in 6% of the blood glucose curves performed during the stabilization phase, was significantly associated with a dose rate of 0.75 IU/kg or more twice daily. This further highlights the need for cautious stepwise changes in insulin dose. The protocol used in the present study is suitable for and easy to use in practice. This study confirmed the efficacy and safety of porcine lente insulin (Caninsulin) in diabetic cats under field conditions.

    Original languageEnglish
    Pages (from-to)439-51
    Number of pages13
    JournalJournal of Feline Medicine and Surgery
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - 2008

    Keywords

    • Animals
    • Area Under Curve
    • Blood Glucose
    • Cat Diseases
    • Cats
    • Diabetes Mellitus
    • Dose-Response Relationship, Drug
    • Female
    • Hypoglycemic Agents
    • Insulin, Long-Acting
    • Male
    • Prospective Studies
    • Remission Induction
    • Safety
    • Swine
    • Treatment Outcome

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