Transpeptidation and reverse proteolysis and their consequences for immunity

Celia R Berkers, Annemieke de Jong, Huib Ovaa, Boris Rodenko

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Reverse proteolysis and transpeptidation lead to the generation of polypeptide sequences that cannot be inferred directly from genome sequences as they are post-translational phenomena. These phenomena have so far received little attention although the physiological consequences may reach far. The protease-mediated synthesis of several immunodominant MHC class I antigens was recently reported, underscoring its importance to immunity. Reverse proteolytic and transpeptidation mechanisms as well as conditions that favor successful protease-catalyzed synthetic events are discussed here.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalInternational Journal of Biochemistry & Cell Biology
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Keywords

  • Animals
  • Antigen Presentation
  • Catalysis
  • Endopeptidases
  • Histocompatibility Antigens Class I
  • Humans
  • Immunity
  • Models, Biological
  • Peptides
  • Protein Processing, Post-Translational

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