Abstract
Reverse proteolysis and transpeptidation lead to the generation of polypeptide sequences that cannot be inferred directly from genome sequences as they are post-translational phenomena. These phenomena have so far received little attention although the physiological consequences may reach far. The protease-mediated synthesis of several immunodominant MHC class I antigens was recently reported, underscoring its importance to immunity. Reverse proteolytic and transpeptidation mechanisms as well as conditions that favor successful protease-catalyzed synthetic events are discussed here.
Original language | English |
---|---|
Pages (from-to) | 66-71 |
Number of pages | 6 |
Journal | International Journal of Biochemistry & Cell Biology |
Volume | 41 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2009 |
Externally published | Yes |
Keywords
- Animals
- Antigen Presentation
- Catalysis
- Endopeptidases
- Histocompatibility Antigens Class I
- Humans
- Immunity
- Models, Biological
- Peptides
- Protein Processing, Post-Translational