Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

Kimberly M. Bonger; Tom Wennekes; Sebastiaan V. P. de Lavoir; Davide Esposito; Richard J. B. H. N. van den Berg; Remy E. J. N. Litjens; Gijs A. van der Marel

doi:10.1002/qsar.200540198

Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

Kimberly M. Bonger
, Tom Wennekes
, Sebastiaan V. P. de Lavoir
, Davide Esposito
, Richard J. B. H. N. van den Berg
, Remy E. J. N. Litjens
, Gijs A. van der Marel

Leiden University
Leiden University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The preparation of highly functionalized pyrrolidines by a tandem Staudinger/aza-Wittig/Ugi Three-Component Reaction (SAWU-3CR) is presented. The SAWU-3CR was applied on two different carbohydrate derived 4-azidopentanals and two libraries of chemically diverse products were prepared.

Original language	English
Pages (from-to)	491-503
Journal	QSAR & Combinatorial Science
Volume	25
Issue number	5-6
DOIs	https://doi.org/10.1002/qsar.200540198
Publication status	Published - 2006
Externally published	Yes

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Bonger, K. M., Wennekes, T., de Lavoir, S. V. P., Esposito, D., van den Berg, R. J. B. H. N., Litjens, R. E. J. N., & van der Marel, G. A. (2006). Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction. QSAR & Combinatorial Science, 25(5-6), 491-503. https://doi.org/10.1002/qsar.200540198

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title = "Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction",

abstract = "The preparation of highly functionalized pyrrolidines by a tandem Staudinger/aza-Wittig/Ugi Three-Component Reaction (SAWU-3CR) is presented. The SAWU-3CR was applied on two different carbohydrate derived 4-azidopentanals and two libraries of chemically diverse products were prepared.",

author = "Bonger, \{Kimberly M.\} and Tom Wennekes and \{de Lavoir\}, \{Sebastiaan V. P.\} and Davide Esposito and \{van den Berg\}, \{Richard J. B. H. N.\} and Litjens, \{Remy E. J. N.\} and \{van der Marel\}, \{Gijs A.\}",

year = "2006",

doi = "10.1002/qsar.200540198",

language = "English",

volume = "25",

pages = "491--503",

journal = "QSAR \& Combinatorial Science",

issn = "1611-020X",

publisher = "Wiley",

number = "5-6",

}

Bonger, KM, Wennekes, T, de Lavoir, SVP, Esposito, D, van den Berg, RJBHN, Litjens, REJN & van der Marel, GA 2006, 'Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction', QSAR & Combinatorial Science, vol. 25, no. 5-6, pp. 491-503. https://doi.org/10.1002/qsar.200540198

Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction. / Bonger, Kimberly M.; Wennekes, Tom; de Lavoir, Sebastiaan V. P. et al.
In: QSAR & Combinatorial Science, Vol. 25, No. 5-6, 2006, p. 491-503.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

AU - Bonger, Kimberly M.

AU - Wennekes, Tom

AU - de Lavoir, Sebastiaan V. P.

AU - Esposito, Davide

AU - van den Berg, Richard J. B. H. N.

AU - Litjens, Remy E. J. N.

AU - van der Marel, Gijs A.

PY - 2006

Y1 - 2006

N2 - The preparation of highly functionalized pyrrolidines by a tandem Staudinger/aza-Wittig/Ugi Three-Component Reaction (SAWU-3CR) is presented. The SAWU-3CR was applied on two different carbohydrate derived 4-azidopentanals and two libraries of chemically diverse products were prepared.

AB - The preparation of highly functionalized pyrrolidines by a tandem Staudinger/aza-Wittig/Ugi Three-Component Reaction (SAWU-3CR) is presented. The SAWU-3CR was applied on two different carbohydrate derived 4-azidopentanals and two libraries of chemically diverse products were prepared.

U2 - 10.1002/qsar.200540198

DO - 10.1002/qsar.200540198

M3 - Article

SN - 1611-020X

VL - 25

SP - 491

EP - 503

JO - QSAR & Combinatorial Science

JF - QSAR & Combinatorial Science

IS - 5-6

ER -

Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

Abstract

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