Tranexamic acid-encapsulating thermosensitive liposomes for site-specific pharmaco-laser therapy of port wine stains

M. Ingmar Van Raath, Ruud Weijer, Gia Hung Nguyen, Bernard Choi, Anton I. De Kroon, Michal Heger*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Site-specific pharmaco-laser therapy (SSPLT) is a developmental stage treatment modality designed to non-invasively remove superficial vascular pathologies such as port wine stains (PWS) by combining conventional laser therapy with the prior administration of a prothrombotic and/or antifibrinolytic pharmaceutical-containing drug delivery system. For the Delivered by Ingenta to: Elsevier BV antifibrinolytic SSPLT component, IP: six 203.56.241.128 different PEGylated On: thermosensitive Tue, 06 Sep 2016 liposomal 15:26:10 formulations encapsulating tranexamic acid (TA), a potent antifibrinolytic

Original languageEnglish
Pages (from-to)1617-1640
Number of pages24
JournalJournal of Biomedical Nanotechnology
Volume12
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • Drug delivery system
  • Fibrinolysis
  • Fluorescamine derivatization
  • Heat-Induced release
  • Thermosensitive liposomes

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