Introduction: A variety of drugs, which are frequently prescribed to older people, have anticholinergic and sedative effects whereby they may impair cognitive and physical function. Although substantial inter-individual variation in anticholinergic and sedative exposure has been documented, little is known about subpopulations with distinct trajectories of exposure. Methods: Data from the Longitudinal Aging Study Amsterdam (LASA), an ongoing Dutch population-based cohort study, collected over 20 years (1992-2012) at seven occasions, were analyzed. On each occasion, cumulative anticholinergic and sedative exposure was quantified with the Drug Burden Index, a linear additive pharmacological dose-response model. The most likely number of trajectories were empirically derived with Latent Class Growth Analysis using "Goodness of fit" statistics. Trajectories were then compared on physical and cognitive function. Results: A total of 763 participants completed all follow-ups (61% women; mean age 83, ±6). "Goodness of fit" statistics (Bayesian In-formation Criterion = 22916, Bootstrapped Likelihood Ratio Test of 3 vs. 2 classes = 514.12 p
Original languageEnglish
Number of pages1
Publication statusPublished - 1 Sept 2017
Event13th International Congress of the European Union Geriatric Medicine Society - Nice, France
Duration: 20 Sept 201722 Sept 2017


Conference13th International Congress of the European Union Geriatric Medicine Society
Internet address


  • cholinergic receptor blocking agent
  • sedative agent
  • aged
  • aging
  • cognition
  • cohort analysis
  • comorbidity
  • dose response
  • Dutchman
  • entropy
  • female
  • human
  • long term exposure
  • major clinical study
  • male
  • statistics
  • very elderly


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