Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells

F R Cassee; W H Stenhuis; J P Groten; V J Feron

doi:10.1016/S0940-2993(96)80060-1

Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells

F R Cassee, W H Stenhuis, J P Groten, V J Feron

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Experimentelle Pathologie
Volume	48
Issue number	6
DOIs	https://doi.org/10.1016/S0940-2993(96)80060-1
Publication status	Published - Nov 1996
Externally published	Yes

Keywords

Acrolein/toxicity
Aldehyde Dehydrogenase/analysis
Animals
Cell Line
Cell Survival/drug effects
Epithelium/drug effects
Formaldehyde/toxicity
Humans
Nasal Mucosa/drug effects
Rats

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10.1016/S0940-2993(96)80060-1

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title = "Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells",

abstract = "In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes.",

keywords = "Acrolein/toxicity, Aldehyde Dehydrogenase/analysis, Animals, Cell Line, Cell Survival/drug effects, Epithelium/drug effects, Formaldehyde/toxicity, Humans, Nasal Mucosa/drug effects, Rats",

author = "Cassee, {F R} and Stenhuis, {W H} and Groten, {J P} and Feron, {V J}",

year = "1996",

month = nov,

doi = "10.1016/S0940-2993(96)80060-1",

language = "English",

volume = "48",

pages = "481--483",

journal = "Experimentelle Pathologie",

issn = "0940-2993",

publisher = "Urban und Fischer Verlag Jena",

number = "6",

}

TY - JOUR

T1 - Toxicity of formaldehyde and acrolein mixtures

T2 - in vitro studies using nasal epithelial cells

AU - Cassee, F R

AU - Stenhuis, W H

AU - Groten, J P

AU - Feron, V J

PY - 1996/11

Y1 - 1996/11

N2 - In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes.

AB - In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes.

KW - Acrolein/toxicity

KW - Aldehyde Dehydrogenase/analysis

KW - Animals

KW - Cell Line

KW - Cell Survival/drug effects

KW - Epithelium/drug effects

KW - Formaldehyde/toxicity

KW - Humans

KW - Nasal Mucosa/drug effects

KW - Rats

U2 - 10.1016/S0940-2993(96)80060-1

DO - 10.1016/S0940-2993(96)80060-1

M3 - Article

C2 - 8954326

SN - 0940-2993

VL - 48

SP - 481

EP - 483

JO - Experimentelle Pathologie

JF - Experimentelle Pathologie

IS - 6

ER -

Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells

Abstract

Keywords

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