Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment

Keyphrases

• Induced Pluripotent Stem Cells (iPSCs) 100%
• Animal-free 100%
• Stem Cell-derived 100%
• Neurotoxicity Screening 100%
• Neuronal Model 100%
• Seizure Liability 100%
• 4-aminopyridine 33%
• Seed Density 33%
• Developmental Pattern 16%
• Commercially Available 16%
• Induced Effect 16%
• Rodents 16%
• Animal Experiment 16%
• Chemically Induced 16%
• Primary Culture 16%
• Neuronal Network 16%
• In Vitro Alternatives 16%
• Screening Tool 16%
• Neuronal Activity 16%
• Immunofluorescent Staining 16%
• Multi-well 16%
• Spontaneous Activity 16%
• Inhibitory Cells 16%
• Microelectrode Array 16%
• Interspecies Translation 16%
• Model Composition 16%
• Primary Cortical Neurons 16%
• Burst Effect 16%
• Picrotoxin 16%
• Drug Attrition 16%
• Drug Seizures 16%
• Excitatory Cells 16%

Neuroscience

• Neurotoxicity 100%
• In Vitro 100%
• Stem Cell 100%
• 4-Aminopyridine 33%
• Behavior (Neuroscience) 16%
• Staining Technique 16%
• Neuronal Activity 16%
• Strychnine 16%
• Primary Culture 16%
• Picrotoxin 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Neurotoxicity 100%
• 4-Aminopyridine 100%
• Primary Culture 50%
• Strychnine 50%
• Picrotoxin 50%