Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

Therese Buskas; Sampat Ingale; Geert J. Boons

doi:10.1002/anie.200501818

Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

Therese Buskas^*, Sampat Ingale, Geert J. Boons

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

(Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice.

Original language	English
Pages (from-to)	5985-5988
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	37
DOIs	https://doi.org/10.1002/anie.200501818
Publication status	Published - 19 Sept 2005
Externally published	Yes

Keywords

Antitumor agents
Glycopeptides
Liposomes
Solid-phase synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200501818

Cite this

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title = "Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen",

abstract = "(Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice.",

keywords = "Antitumor agents, Glycopeptides, Liposomes, Solid-phase synthesis",

author = "Therese Buskas and Sampat Ingale and Boons, {Geert J.}",

year = "2005",

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language = "English",

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pages = "5985--5988",

journal = "Angewandte Chemie - International Edition",

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Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen. / Buskas, Therese; Ingale, Sampat; Boons, Geert J.
In: Angewandte Chemie - International Edition, Vol. 44, No. 37, 19.09.2005, p. 5985-5988.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Towards a fully synthetic carbohydrate-based anticancer vaccine

T2 - Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

AU - Buskas, Therese

AU - Ingale, Sampat

AU - Boons, Geert J.

PY - 2005/9/19

Y1 - 2005/9/19

N2 - (Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice.

AB - (Chemical Equation Presented) A spoonful of sugar ... A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide Tepitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice.

KW - Antitumor agents

KW - Glycopeptides

KW - Liposomes

KW - Solid-phase synthesis

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U2 - 10.1002/anie.200501818

DO - 10.1002/anie.200501818

M3 - Article

C2 - 16108081

AN - SCOPUS:25144435051

SN - 1433-7851

VL - 44

SP - 5985

EP - 5988

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 37

ER -

Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen

Abstract

Keywords

UN SDGs

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