Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis

M. Olsson; L. Tintle; M. Kierczak; M. Perloski; N. Tonomura; A. Lundquist; E. Murén; M. Fels; K. Tengvall; G. Pielberg; C. Dufaure de Citres; L. Dorso; J. Abadie; J. Hanson; A. Thomas; P.A.J. Leegwater; A. Hedhammar; K. Lindblad-Toh; J.R. Meadows

doi:10.1371/journal.pone.0075242.

Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis

M. Olsson, L. Tintle, M. Kierczak, M. Perloski, N. Tonomura, A. Lundquist, E. Murén, M. Fels, K. Tengvall, G. Pielberg, C. Dufaure de Citres, L. Dorso, J. Abadie, J. Hanson, A. Thomas, P.A.J. Leegwater, A. Hedhammar, K. Lindblad-Toh, J.R. Meadows

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Abstract

Abstract Autoinflammatory disease (AID) manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever, arthritis, breed specific secondary dermatitis, otitis and systemic reactive amyloidosis) in a canine comparative model, the pure bred Chinese Shar-Pei. Analysis of 255 DNA samples revealed a shared locus on chromosome 13 spanning two peaks of association. A three-marker haplotype based on the most significant SNP (p

Original language	English
Pages (from-to)	e75242
Number of pages	1
Journal	PLoS One
Volume	8
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0075242.
Publication status	Published - 2013

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Olsson, M., Tintle, L., Kierczak, M., Perloski, M., Tonomura, N., Lundquist, A., Murén, E., Fels, M., Tengvall, K., Pielberg, G., Dufaure de Citres, C., Dorso, L., Abadie, J., Hanson, J., Thomas, A., Leegwater, P. A. J., Hedhammar, A., Lindblad-Toh, K., & Meadows, J. R. (2013). Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis. PLoS One, 8(10), e75242. https://doi.org/10.1371/journal.pone.0075242.

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title = "Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis",

abstract = "Abstract Autoinflammatory disease (AID) manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever, arthritis, breed specific secondary dermatitis, otitis and systemic reactive amyloidosis) in a canine comparative model, the pure bred Chinese Shar-Pei. Analysis of 255 DNA samples revealed a shared locus on chromosome 13 spanning two peaks of association. A three-marker haplotype based on the most significant SNP (p",

author = "M. Olsson and L. Tintle and M. Kierczak and M. Perloski and N. Tonomura and A. Lundquist and E. Mur{\'e}n and M. Fels and K. Tengvall and G. Pielberg and {Dufaure de Citres}, C. and L. Dorso and J. Abadie and J. Hanson and A. Thomas and P.A.J. Leegwater and A. Hedhammar and K. Lindblad-Toh and J.R. Meadows",

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doi = "10.1371/journal.pone.0075242.",

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Olsson, M, Tintle, L, Kierczak, M, Perloski, M, Tonomura, N, Lundquist, A, Murén, E, Fels, M, Tengvall, K, Pielberg, G, Dufaure de Citres, C, Dorso, L, Abadie, J, Hanson, J, Thomas, A, Leegwater, PAJ, Hedhammar, A, Lindblad-Toh, K & Meadows, JR 2013, 'Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis', PLoS One, vol. 8, no. 10, pp. e75242. https://doi.org/10.1371/journal.pone.0075242.

TY - JOUR

T1 - Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis

AU - Olsson, M.

AU - Tintle, L.

AU - Kierczak, M.

AU - Perloski, M.

AU - Tonomura, N.

AU - Lundquist, A.

AU - Murén, E.

AU - Fels, M.

AU - Tengvall, K.

AU - Pielberg, G.

AU - Dufaure de Citres, C.

AU - Dorso, L.

AU - Abadie, J.

AU - Hanson, J.

AU - Thomas, A.

AU - Leegwater, P.A.J.

AU - Hedhammar, A.

AU - Lindblad-Toh, K.

AU - Meadows, J.R.

PY - 2013

Y1 - 2013

N2 - Abstract Autoinflammatory disease (AID) manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever, arthritis, breed specific secondary dermatitis, otitis and systemic reactive amyloidosis) in a canine comparative model, the pure bred Chinese Shar-Pei. Analysis of 255 DNA samples revealed a shared locus on chromosome 13 spanning two peaks of association. A three-marker haplotype based on the most significant SNP (p

AB - Abstract Autoinflammatory disease (AID) manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever, arthritis, breed specific secondary dermatitis, otitis and systemic reactive amyloidosis) in a canine comparative model, the pure bred Chinese Shar-Pei. Analysis of 255 DNA samples revealed a shared locus on chromosome 13 spanning two peaks of association. A three-marker haplotype based on the most significant SNP (p

U2 - 10.1371/journal.pone.0075242.

DO - 10.1371/journal.pone.0075242.

M3 - Article

SN - 1932-6203

VL - 8

SP - e75242

JO - PLoS One

JF - PLoS One

IS - 10

ER -

Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis

Abstract

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