The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

Teunis J P Van Dam; Gabrielle Wheway; Gisela G. Slaats; Martijn A Huynen; Rachel H. Giles

doi:10.1186/2046-2530-2-7

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

Teunis J P Van Dam^*, Gabrielle Wheway, Gisela G. Slaats, Martijn A Huynen, Rachel H. Giles

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.

Original language	English
Article number	7
Journal	Cilia
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/2046-2530-2-7
Publication status	Published - 31 May 2013
Externally published	Yes

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title = "The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium",

abstract = "The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.",

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AU - Slaats, Gisela G.

AU - Huynen, Martijn A

AU - Giles, Rachel H.

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AB - The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.

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ER -

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

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