The role of the ubiquitin-proteasome pathway in MHC class I antigen processing: implications for vaccine design

Keyphrases

• Ubiquitin-proteasome System 100%
• Vaccine Design 100%
• MHC Class I Antigen Presentation 100%
• Interferon-γ 75%
• Immunoproteasome 50%
• Virus 25%
• MHC Class I Molecules 25%
• Antigen Processing 25%
• CTL Epitope 25%
• Cellular Processes 25%
• Tumor 25%
• Antigen-presenting 25%
• PA28 25%
• Proteasome Subunits 25%
• Proteasome Activator 25%
• Peptide Fragments 25%
• Eukaryotic Cells 25%
• Cell Surface 25%
• Proteolysis 25%
• Anticancer 25%
• Endogenous Protein 25%
• Antigenic Peptide 25%
• T Cell Vaccine 25%
• Protein Sequence 25%
• Large Proteins 25%
• Cytotoxic T Lymphocytes 25%
• Computer-assisted 25%
• Sequence-based 25%
• Small Peptides 25%
• Rational Basis 25%
• Catalytic Subunit 25%
• New Antivirals 25%
• Cleavage Specificity 25%
• Proteasome System 25%
• Targeted Protein Degradation 25%
• Proteostasis Regulators 25%
• Peptide Production 25%
• Multisubunit Enzyme Complex 25%

Immunology and Microbiology

• MHC Class I 100%
• Antigen Presentation 100%
• Proteasome 100%
• Ubiquitins 100%
• Protein Degradation 16%
• Peptides 16%
• Virus 8%
• Cytotoxic T Cell 8%
• Epitope 8%
• Cell Surface 8%
• Eukaryotic Cell 8%
• Amino Acid Sequence 8%
• Enzyme Active Site 8%
• T Cell 8%

Biochemistry, Genetics and Molecular Biology

• MHC Class I 100%
• Antigen Presentation 100%
• Proteasome 100%
• Ubiquitin 100%
• Protein Catabolism 8%
• Peptide Sequence 8%
• Anticancer 8%
• Enzyme 8%
• Enzyme Active Site 8%
• T Cell 8%
• Cytotoxic T Cell 8%
• Proteolysis 8%