Abstract
The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-gamma. Two of these are the alpha and beta subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen.
Original language | English |
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Pages (from-to) | 165-9 |
Number of pages | 5 |
Journal | Molecular Immunology |
Volume | 39 |
Issue number | 3-4 |
Publication status | Published - 2002 |
Keywords
- Animals
- Antigen Presentation
- Antigens, Neoplasm
- Epitopes, T-Lymphocyte
- Histocompatibility Antigens Class I
- Humans
- Muscle Proteins
- Proteasome Endopeptidase Complex
- Proteins
- T-Lymphocytes, Cytotoxic
- Journal Article
- Review