The role of the proteasome activator PA28 in MHC class I antigen processing

Alice Sijts, Yuancheng Sun, Katarina Janek, Sylvie Kral, Annettte Paschen, Dirk Schadendorf, Peter M Kloetzel

    Research output: Contribution to journalArticleAcademicpeer-review


    The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-gamma. Two of these are the alpha and beta subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen.

    Original languageEnglish
    Pages (from-to)165-9
    Number of pages5
    JournalMolecular Immunology
    Issue number3-4
    Publication statusPublished - 2002


    • Animals
    • Antigen Presentation
    • Antigens, Neoplasm
    • Epitopes, T-Lymphocyte
    • Histocompatibility Antigens Class I
    • Humans
    • Muscle Proteins
    • Proteasome Endopeptidase Complex
    • Proteins
    • T-Lymphocytes, Cytotoxic
    • Journal Article
    • Review


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