The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Shareen H Doak; Martin J D Clift; Anna Costa; Christiaan Delmaar; Ilse Gosens; Sabina Halappanavar; Sean Kelly; Willie J G M Pejinenburg; Barbara Rothen-Rutishauser; Roel P F Schins; Vicki Stone; Lang Tran; Martina G Vijver; Ulla Vogel; Wendel Wohlleben; Flemming R Cassee

doi:10.1002/smll.202200231

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Shareen H Doak
, Martin J D Clift
, Anna Costa
, Christiaan Delmaar
, Ilse Gosens
, Sabina Halappanavar
, Sean Kelly
, Willie J G M Pejinenburg
, Barbara Rothen-Rutishauser
, Roel P F Schins
, Vicki Stone
, Lang Tran
, Martina G Vijver
, Ulla Vogel
, Wendel Wohlleben
, Flemming R Cassee

IRAS OH Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

Original language	English
Article number	2200231
Pages (from-to)	1-11
Number of pages	11
Journal	Small
Volume	18
Issue number	17
Early online date	24 Mar 2022
DOIs	https://doi.org/10.1002/smll.202200231
Publication status	Published - 27 Apr 2022

Bibliographical note

Funding Information:
The authors wish to acknowledge the funding from the European Union's Horizon 2020 research and innovation program for the PATROLS project, under grant agreement No. 760813. S.H. acknowledges funding from Health Canada's Genomics Research and Development Initiative.

Publisher Copyright:
© 2022 The Authors. Small published by Wiley-VCH GmbH.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 12 Responsible Consumption and Production
SDG 13 Climate Action

Keywords

ecotoxicity
in silico models
in vitro 3D models
nanomaterials
nanosafety
physico-chemical characterization

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10.1002/smll.202200231Licence: CC BY

Small - 2022 - Doak - The Road to Achieving the European Commission s Chemicals Strategy for Nanomaterial Sustainability AFinal published version, 1.45 MB

Cite this

Doak, S. H., Clift, M. J. D., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W. J. G. M., Rothen-Rutishauser, B., Schins, R. P. F., Stone, V., Tran, L., Vijver, M. G., Vogel, U., Wohlleben, W., & Cassee, F. R. (2022). The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies. Small, 18(17), 1-11. Article 2200231. https://doi.org/10.1002/smll.202200231

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abstract = "The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.",

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note = "Funding Information: The authors wish to acknowledge the funding from the European Union's Horizon 2020 research and innovation program for the PATROLS project, under grant agreement No. 760813. S.H. acknowledges funding from Health Canada's Genomics Research and Development Initiative. Publisher Copyright: {\textcopyright} 2022 The Authors. Small published by Wiley-VCH GmbH.",

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Doak, SH, Clift, MJD, Costa, A, Delmaar, C, Gosens, I, Halappanavar, S, Kelly, S, Pejinenburg, WJGM, Rothen-Rutishauser, B, Schins, RPF, Stone, V, Tran, L, Vijver, MG, Vogel, U, Wohlleben, W & Cassee, FR 2022, 'The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies', Small, vol. 18, no. 17, 2200231, pp. 1-11. https://doi.org/10.1002/smll.202200231

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KW - nanosafety

KW - physico-chemical characterization

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ER -

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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