TY - JOUR
T1 - The relationship between blood pressure and risk of renal cell carcinoma
AU - Alcala, Karine
AU - Mariosa, Daniela
AU - Smith-Byrne, Karl
AU - Nasrollahzadeh Nesheli, Dariush
AU - Carreras-Torres, Robert
AU - Ardanaz Aicua, Eva
AU - Bondonno, Nicola P
AU - Bonet, Catalina
AU - Brunström, Mattias
AU - Bueno-De-Mesquita, Bas
AU - Chirlaque, María-Dolores
AU - Christakoudi, Sofia
AU - Heath, Alicia K
AU - Kaaks, Rudolf
AU - Katzke, Verena
AU - Krogh, Vittorio
AU - Ljungberg, Börje
AU - Martin, Richard M
AU - May, Anne
AU - Melander, Olle
AU - Palli, Domenico
AU - Rodriguez-Barranco, Miguel
AU - Sacerdote, Carlotta
AU - Stocks, Tanja
AU - Tjønneland, Anne
AU - Travis, Ruth C.
AU - Vermeulen, Roel
AU - Chanock, Stephen
AU - Purdue, Mark
AU - Weiderpass, Elisabete
AU - Muller, David
AU - Brennan, Paul
AU - Johansson, Mattias
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Background: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. Methods: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. Results: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP. Conclusion: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP. © 2022 World Health Organization,. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.
AB - Background: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. Methods: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. Results: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP. Conclusion: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP. © 2022 World Health Organization,. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.
KW - Mendelian randomization
KW - RCC
KW - diastolic blood pressure
KW - kidney cancer
KW - systolic blood pressure
U2 - 10.1093/ije/dyac042
DO - 10.1093/ije/dyac042
M3 - Article
SN - 0300-5771
VL - 51
SP - 1317
EP - 1327
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 4
ER -