The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength

Wim de Lau; Weng Chuan Peng; Piet Gros; Hans Clevers

doi:10.1101/gad.235473.113

The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength

Wim de Lau
, Weng Chuan Peng
, Piet Gros
, Hans Clevers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.

Original language	English
Pages (from-to)	305-316
Number of pages	12
Journal	Genes and Development
Volume	28
Issue number	4
DOIs	https://doi.org/10.1101/gad.235473.113
Publication status	Published - 15 Feb 2014

Keywords

Lgr5
Rnf43/Znrf3
Rspondin
Wnt signal regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1101/gad.235473.113

Genes Dev.-2014-de Lau-305-16Final published version, 1.02 MB

Cite this

@article{cc336358ea4d4b1eb813306099575ac7,

title = "The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength",

abstract = "Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.",

keywords = "Lgr5, Rnf43/Znrf3, Rspondin, Wnt signal regulation",

author = "\{de Lau\}, Wim and Peng, \{Weng Chuan\} and Piet Gros and Hans Clevers",

year = "2014",

month = feb,

day = "15",

doi = "10.1101/gad.235473.113",

language = "English",

volume = "28",

pages = "305--316",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "4",

}

TY - JOUR

T1 - The R-spondin/Lgr5/Rnf43 module

T2 - Regulator of Wnt signal strength

AU - de Lau, Wim

AU - Peng, Weng Chuan

AU - Gros, Piet

AU - Clevers, Hans

PY - 2014/2/15

Y1 - 2014/2/15

N2 - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.

AB - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.

KW - Lgr5

KW - Rnf43/Znrf3

KW - Rspondin

KW - Wnt signal regulation

UR - https://www.scopus.com/pages/publications/84893947796

U2 - 10.1101/gad.235473.113

DO - 10.1101/gad.235473.113

M3 - Article

C2 - 24532711

AN - SCOPUS:84893947796

SN - 0890-9369

VL - 28

SP - 305

EP - 316

JO - Genes and Development

JF - Genes and Development

IS - 4

ER -

The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this