TY - JOUR
T1 - The R-spondin/Lgr5/Rnf43 module
T2 - Regulator of Wnt signal strength
AU - de Lau, Wim
AU - Peng, Weng Chuan
AU - Gros, Piet
AU - Clevers, Hans
PY - 2014/2/15
Y1 - 2014/2/15
N2 - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.
AB - Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.
KW - Lgr5
KW - Rnf43/Znrf3
KW - Rspondin
KW - Wnt signal regulation
UR - http://www.scopus.com/inward/record.url?scp=84893947796&partnerID=8YFLogxK
U2 - 10.1101/gad.235473.113
DO - 10.1101/gad.235473.113
M3 - Article
C2 - 24532711
AN - SCOPUS:84893947796
SN - 0890-9369
VL - 28
SP - 305
EP - 316
JO - Genes and Development
JF - Genes and Development
IS - 4
ER -
