The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase

M Kleerebezem; M Heutink; H de Cock; J Tommassen

The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase

M Kleerebezem, M Heutink, H de Cock, J Tommassen

Sub Molecular Microbiology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The phenotypes of temperature-sensitive qmeA and fabI mutants of Escherichia coli appear to be very similar. Furthermore, the qmeA mutation could be complemented by the fabI gene on a plasmid, and the fabI allele derived from the qmeA mutant strain harbours a nucleotide substitution identical to that from a previously characterized fabI mutant. These results show that the qmeA gene is, in fact, identical to the fabI gene, which encodes enoyl-ACP reductase, involved in fatty acid elongation.

Original language	English
Pages (from-to)	609-13
Number of pages	5
Journal	Research in Microbiology
Volume	147
Issue number	8
Publication status	Published - 1996

Keywords

Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)
Escherichia coli
Genes, Bacterial
In Vitro Techniques
Mutation
Oxidoreductases
Phenotype

Cite this

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title = "The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase",

abstract = "The phenotypes of temperature-sensitive qmeA and fabI mutants of Escherichia coli appear to be very similar. Furthermore, the qmeA mutation could be complemented by the fabI gene on a plasmid, and the fabI allele derived from the qmeA mutant strain harbours a nucleotide substitution identical to that from a previously characterized fabI mutant. These results show that the qmeA gene is, in fact, identical to the fabI gene, which encodes enoyl-ACP reductase, involved in fatty acid elongation.",

keywords = "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific), Escherichia coli, Genes, Bacterial, In Vitro Techniques, Mutation, Oxidoreductases, Phenotype",

author = "M Kleerebezem and M Heutink and {de Cock}, H and J Tommassen",

year = "1996",

language = "English",

volume = "147",

pages = "609--13",

journal = "Research in Microbiology",

issn = "0923-2508",

publisher = "Elsevier Masson SAS",

number = "8",

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TY - JOUR

T1 - The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase

AU - Kleerebezem, M

AU - Heutink, M

AU - de Cock, H

AU - Tommassen, J

PY - 1996

Y1 - 1996

N2 - The phenotypes of temperature-sensitive qmeA and fabI mutants of Escherichia coli appear to be very similar. Furthermore, the qmeA mutation could be complemented by the fabI gene on a plasmid, and the fabI allele derived from the qmeA mutant strain harbours a nucleotide substitution identical to that from a previously characterized fabI mutant. These results show that the qmeA gene is, in fact, identical to the fabI gene, which encodes enoyl-ACP reductase, involved in fatty acid elongation.

AB - The phenotypes of temperature-sensitive qmeA and fabI mutants of Escherichia coli appear to be very similar. Furthermore, the qmeA mutation could be complemented by the fabI gene on a plasmid, and the fabI allele derived from the qmeA mutant strain harbours a nucleotide substitution identical to that from a previously characterized fabI mutant. These results show that the qmeA gene is, in fact, identical to the fabI gene, which encodes enoyl-ACP reductase, involved in fatty acid elongation.

KW - Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)

KW - Escherichia coli

KW - Genes, Bacterial

KW - In Vitro Techniques

KW - Mutation

KW - Oxidoreductases

KW - Phenotype

M3 - Article

C2 - 9157486

SN - 0923-2508

VL - 147

SP - 609

EP - 613

JO - Research in Microbiology

JF - Research in Microbiology

IS - 8

ER -

The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase

Abstract

Keywords

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