The neurobiology of social play and its rewarding value in rats

Louk J M J Vanderschuren, E J Marijke Achterberg, Viviana Trezza

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    In the young of many mammalian species, including humans, a vigorous and highly rewarding social activity is abundantly expressed, known as social play behaviour. Social play is thought to be important for the development of social, cognitive and emotional processes and their neural underpinnings, and it is disrupted in pediatric psychiatric disorders. Here, we summarize recent progress in our understanding of the brain mechanisms of social play behaviour, with a focus on its rewarding properties. Opioid, endocannabinoid, dopamine and noradrenaline systems play a prominent role in the modulation of social play. Of these, dopamine is particularly important for the motivational properties of social play. The nucleus accumbens has been identified as a key site for opioid and dopamine modulation of social play. Endocannabinoid influences on social play rely on the basolateral amygdala, whereas noradrenaline modulates social play through the basolateral amygdala, habenula and prefrontal cortex. In sum, social play behaviour is the result of coordinated activity in a network of corticolimbic structures, and its monoamine, opioid and endocannabinoid innervation.

    Original languageEnglish
    Pages (from-to)86-105
    Number of pages20
    JournalNeuroscience and Biobehavioral Reviews
    Volume70
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Social play behaviour
    • Reward
    • Place conditioning
    • Operant conditioning
    • Opioids
    • Endocannabinoids
    • Dopamine
    • Noradrenaline
    • Prefrontal cortex
    • Nucleus accumbens
    • Amygdala

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