TY - JOUR
T1 - The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle
AU - Nguyen, T.K.A.
AU - Koets, A.P.
AU - Santema, W.I.
AU - van Eden, W.
AU - Rutten, V.P.M.G.
AU - van Rhijn, I.
PY - 2009
Y1 - 2009
N2 - Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.
AB - Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-67650227022&partnerID=MN8TOARS
U2 - 10.1016/j.vaccine.2009.05.078
DO - 10.1016/j.vaccine.2009.05.078
M3 - Article
SN - 0264-410X
VL - 27
SP - 4818
EP - 4825
JO - Vaccine
JF - Vaccine
IS - 35
ER -
