The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

N Vastenhout; S J van Rijn; F M Riemers; M A Tryfonidou; B P Meij; L C Penning

doi:10.1016/j.tvjl.2018.08.012

The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

N Vastenhout, S J van Rijn, F M Riemers, M A Tryfonidou, B P Meij, L C Penning

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.

Original language	English
Pages (from-to)	19-21
Number of pages	3
Journal	Veterinary Journal
Volume	240
DOIs	https://doi.org/10.1016/j.tvjl.2018.08.012
Publication status	Published - 2018

Keywords

Dog
Hypophysectomy
Pituitary adenoma
Quantitative RT-PCR
Survival time

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tvjl.2018.08.012

vastenhoutFinal published version, 411 KBLicence: Taverne

Cite this

@article{b6791f2a68a144819ab56de417f0e40e,

title = "The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas",

abstract = "Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.",

keywords = "Dog, Hypophysectomy, Pituitary adenoma, Quantitative RT-PCR, Survival time",

author = "N Vastenhout and {van Rijn}, {S J} and Riemers, {F M} and Tryfonidou, {M A} and Meij, {B P} and Penning, {L C}",

year = "2018",

doi = "10.1016/j.tvjl.2018.08.012",

language = "English",

volume = "240",

pages = "19--21",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

}

TY - JOUR

T1 - The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

AU - Vastenhout, N

AU - van Rijn, S J

AU - Riemers, F M

AU - Tryfonidou, M A

AU - Meij, B P

AU - Penning, L C

PY - 2018

Y1 - 2018

N2 - Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.

AB - Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.

KW - Dog

KW - Hypophysectomy

KW - Pituitary adenoma

KW - Quantitative RT-PCR

KW - Survival time

U2 - 10.1016/j.tvjl.2018.08.012

DO - 10.1016/j.tvjl.2018.08.012

M3 - Article

C2 - 30268327

SN - 1090-0233

VL - 240

SP - 19

EP - 21

JO - Veterinary Journal

JF - Veterinary Journal

ER -

The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this