The missing link: chemokine receptors and tissue matrix breakdown in COPD

Joost J Smit; Nicholas W Lukacs

doi:10.1016/j.tips.2006.09.003

The missing link: chemokine receptors and tissue matrix breakdown in COPD

Joost J Smit, Nicholas W Lukacs

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted during acute and chronic inflammation of the lung. The factors involved might be both a biomarker and a therapeutic target in COPD.

Original language	English
Pages (from-to)	555-7
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.tips.2006.09.003
Publication status	Published - Nov 2006

Keywords

Animals
Chemotaxis
Extracellular Matrix
Humans
Lung
Macrophages, Alveolar
Neutrophils
Peptide Fragments
Pulmonary Disease, Chronic Obstructive
Receptors, Chemokine
Receptors, Interleukin-8B

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10.1016/j.tips.2006.09.003

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title = "The missing link: chemokine receptors and tissue matrix breakdown in COPD",

abstract = "Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted during acute and chronic inflammation of the lung. The factors involved might be both a biomarker and a therapeutic target in COPD.",

keywords = "Animals, Chemotaxis, Extracellular Matrix, Humans, Lung, Macrophages, Alveolar, Neutrophils, Peptide Fragments, Pulmonary Disease, Chronic Obstructive, Receptors, Chemokine, Receptors, Interleukin-8B",

author = "Smit, {Joost J} and Lukacs, {Nicholas W}",

year = "2006",

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doi = "10.1016/j.tips.2006.09.003",

language = "English",

volume = "27",

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T2 - chemokine receptors and tissue matrix breakdown in COPD

AU - Smit, Joost J

AU - Lukacs, Nicholas W

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Y1 - 2006/11

N2 - Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted during acute and chronic inflammation of the lung. The factors involved might be both a biomarker and a therapeutic target in COPD.

AB - Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted during acute and chronic inflammation of the lung. The factors involved might be both a biomarker and a therapeutic target in COPD.

KW - Animals

KW - Chemotaxis

KW - Extracellular Matrix

KW - Humans

KW - Lung

KW - Macrophages, Alveolar

KW - Neutrophils

KW - Peptide Fragments

KW - Pulmonary Disease, Chronic Obstructive

KW - Receptors, Chemokine

KW - Receptors, Interleukin-8B

U2 - 10.1016/j.tips.2006.09.003

DO - 10.1016/j.tips.2006.09.003

M3 - Article

C2 - 17000010

SN - 0165-6147

VL - 27

SP - 555

EP - 557

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 11

ER -

The missing link: chemokine receptors and tissue matrix breakdown in COPD

Abstract

Keywords

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