The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes

M.J. Van De Velde; F. Engels; P.A.J. Henricks; P.G.M. Bloemen; F.P. Nijkamp

doi:10.1016/0014-5793(95)00773-3

The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes

M.J. Van De Velde, F. Engels, P.A.J. Henricks, P.G.M. Bloemen, F.P. Nijkamp

Pharmacology

External unknown

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on degranulation of human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 μM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	FEBS Letters
Volume	369
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-5793(95)00773-3
Publication status	Published - 26 Jan 1995

Keywords

13-HODE
CD11b
CD67
degranulation
polymorphonuclear leucocyte
13 hydroxyoctadecadienoic acid
cd 67 antigen
CD11b antigen
fatty acid derivative
formylmethionylleucylphenylalanine
linoleic acid derivative
thrombocyte activating factor
unclassified drug
article
controlled study
flow cytometry
gene expression
human
human cell
neutrophil
normal human
priority journal

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10.1016/0014-5793(95)00773-3

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title = "The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes",

abstract = "The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on degranulation of human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 μM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.",

keywords = "13-HODE, CD11b, CD67, degranulation, polymorphonuclear leucocyte, 13 hydroxyoctadecadienoic acid, cd 67 antigen, CD11b antigen, fatty acid derivative, formylmethionylleucylphenylalanine, linoleic acid derivative, thrombocyte activating factor, unclassified drug, article, controlled study, flow cytometry, gene expression, human, human cell, neutrophil, normal human, priority journal",

author = "{Van De Velde}, M.J. and F. Engels and P.A.J. Henricks and P.G.M. Bloemen and F.P. Nijkamp",

year = "1995",

month = jan,

day = "26",

doi = "10.1016/0014-5793(95)00773-3",

language = "English",

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journal = "FEBS Letters",

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TY - JOUR

T1 - The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes

AU - Van De Velde, M.J.

AU - Engels, F.

AU - Henricks, P.A.J.

AU - Bloemen, P.G.M.

AU - Nijkamp, F.P.

PY - 1995/1/26

Y1 - 1995/1/26

N2 - The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on degranulation of human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 μM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.

AB - The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on degranulation of human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 μM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.

KW - 13-HODE

KW - CD11b

KW - CD67

KW - degranulation

KW - polymorphonuclear leucocyte

KW - 13 hydroxyoctadecadienoic acid

KW - cd 67 antigen

KW - CD11b antigen

KW - fatty acid derivative

KW - formylmethionylleucylphenylalanine

KW - linoleic acid derivative

KW - thrombocyte activating factor

KW - unclassified drug

KW - article

KW - controlled study

KW - flow cytometry

KW - gene expression

KW - human

KW - human cell

KW - neutrophil

KW - normal human

KW - priority journal

U2 - 10.1016/0014-5793(95)00773-3

DO - 10.1016/0014-5793(95)00773-3

M3 - Article

SN - 0014-5793

VL - 369

SP - 301

EP - 304

JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -

The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes

Abstract

Keywords

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