The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition

Matthijs J van Haren, Martin G Thomas, Davide Sartini, David J Barlow, David B Ramsden, Monica Emanuelli, Fábio Klamt, Nathaniel I Martin, Richard B Parsons

King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK.
Universitá Politecnica delle Marche, Department of Clinical Sciences, School of Medicine, Ancona, Italy.
University of Birmingham, Institute of Metabolism and Systems Research, Edgbaston, Birmingham B15 2TH, UK.
Universidade Federal do Rio Grande do Sul, Departmento de Bioquímica, Instituto de Ciêncas Básicas de Saúde, Rua Ramiro Barcelos, Porto Alegre, RS 90035 003, Brazil.
King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London SE1 9NH, UK. Electronic address: [email protected].

Research output: Contribution to journal › Article › Academic › peer-review

Keyphrases

Biochemistry, Genetics and Molecular Biology