The interactions of physical activity levels with the sodium channel protein type 9 subunit alpha and methylene tetrahydrofolate reductase genes are associated with fatigue in women with fibromyalgia

Fernando Estevez-Lopez, Diego Salazar-Tortosa, Blanca Gavilan Carrera, Virginia A. Aparicio, Pedro Acosta-Manzano, Victor Segura-Jimenez, Inmaculada C. Alvarez-Gallardo, Ana Carbonell-Baeza, Diego Munguia-Izquierdo, Rinie Geenen, Eliana Lacerda, Manuel Delgado-Fernandez, Luis J. Martinez-Gonzalez, Jonatan R. Ruiz, Maria J. Alvarez-Cubero

Research output: Contribution to journalMeeting AbstractOther research output

Abstract

Background
People with fibromyalgia identify fatigue as one of the main symptoms of the disease [1]. It is hypothesised that the pathogenesis of fibromyalgia involves a genetic susceptibility that is modulated by environmental factors [2]

Objectives
To examine the possible role of genetic susceptibility for fatigue in southern Spanish women with fibromyalgia, by looking at the possible associations of fatigue and single nucleotide polymorphisms in 34 fibromyalgia candidate-genes, at the interactions between genes, and at the associations between gene-physical activity.

Methods
In this cross-sectional study participated 276 women with fibromyalgia. We extracted DNA from saliva in order to analyse gene-polymorphisms related to fibromyalgia susceptibility, symptoms, or potential mechanisms. Accelerometers registered the participants’ physical activity and sedentary time. Five dimensions of fatigue were assessed with the Multidimensional Fatigue Inventory. Age, body fat (%), and analgesics and antidepressants consumption were considered as confounders in all analyses. Based on the Bonferroni’s and False Discovery Rate (FDR) values, the statistical significance was interpreted.

Results
AT carriers of the rs4453709 polymorphism (sodium channel protein type 9 subunit alpha, SCN9A, gene) showed the highest scores on fatigue. Carriers of the heterozygous genotype of the rs1801133 (methylene tetrahydrofolate reductase, MTHFR, gene) or rs4597545 (SCN9A gene) polymorphisms who were physically active reported lower fatigue compared to their inactive counterparts. Highly sedentary carriers of the homozygous genotype of the rs7607967 polymorphism (AA/GG genotype; SCN9A gene) presented higher fatigue than those with lower levels of sedentary time.

Conclusion
Physical (in)activity behaviours and the SCN9A and MTHFR genes were jointly related to fatigue. Thereby, the potential benefits of following an active lifestyle might be observed more clearly in women with fibromyalgia genetically predispose to higher levels of fatigue.
Original languageEnglish
Article numberTHU0468
Pages (from-to)524-525
Number of pages2
JournalAnnals of the Rheumatic Diseases
Volume78
Issue number2
DOIs
Publication statusPublished - Jun 2019
EventEULAR Annual European Congress of Rheumatology - Feria de Madrid, Madrid, Spain
Duration: 12 Jun 201915 Jun 2019
https://www.congress.eular.org/

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