Abstract
In the present study, the effect of vaccination of guinea pigs with Bordetella pertussis was investigated, 4 days after treatment, on the cholinergic and beta-adrenergic receptor function in isolated tracheal spirals and the number of beta-adrenoceptor binding sites in guinea pig lung. It was found that B. pertussis caused an impairment in the beta-adrenoceptor function and a decrease in its number. Similar results were obtained with endotoxin. Leucocytosis promoting factor, however, was ineffective. These results indicate that endotoxin is the constituent responsible for the beta-adrenoceptor blocking effects of the bacterium. Also the combined whole cell diphteria, B. pertussis and tetanus toxoid vaccine induced a beta-adrenoceptor blockade; the acellular vaccine was less effective. The results obtained with the B. pertussis vaccines are discussed in relation to the possible side-effects that sometimes occur after immunization of infants.
| Original language | English |
|---|---|
| Pages (from-to) | 677-685 |
| Number of pages | 9 |
| Journal | Life Sciences |
| Volume | 38 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 28 Mar 1986 |
Keywords
- beta adrenergic receptor
- carbachol
- diphtheria pertussis tetanus vaccine
- isoprenaline
- pertussis vaccine
- tetanus toxoid
- animal cell
- Bordetella pertussis
- drug efficacy
- drug interaction
- drug receptor binding
- guinea pig
- lung
- nonhuman
- pharmacokinetics
- priority journal
- respiratory system
- trachea
- vaccination
