The hepatitis delta (δ) virus possesses a circular RNA

A. Kos; R. Dijkema; A. C. Arnberg; P. H. Van Der Meide; H. Schellekens

doi:10.1038/323558a0

The hepatitis delta (δ) virus possesses a circular RNA

A. Kos^*
, R. Dijkema
, A. C. Arnberg
, P. H. Van Der Meide
, H. Schellekens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hepatitis delta (δ) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans¹. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing ∼25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

Original language	English
Pages (from-to)	558-560
Number of pages	3
Journal	Nature
Volume	323
Issue number	6088
DOIs	https://doi.org/10.1038/323558a0
Publication status	Published - 1 Dec 1986
Externally published	Yes

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title = "The hepatitis delta (δ) virus possesses a circular RNA",

abstract = "Hepatitis delta (δ) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans1. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing ∼25\% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.",

author = "A. Kos and R. Dijkema and Arnberg, \{A. C.\} and \{Van Der Meide\}, \{P. H.\} and H. Schellekens",

year = "1986",

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doi = "10.1038/323558a0",

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journal = "Nature",

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T1 - The hepatitis delta (δ) virus possesses a circular RNA

AU - Kos, A.

AU - Dijkema, R.

AU - Arnberg, A. C.

AU - Van Der Meide, P. H.

AU - Schellekens, H.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - Hepatitis delta (δ) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans1. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing ∼25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

AB - Hepatitis delta (δ) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans1. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing ∼25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

UR - https://www.scopus.com/pages/publications/0022497925

U2 - 10.1038/323558a0

DO - 10.1038/323558a0

M3 - Article

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AN - SCOPUS:0022497925

SN - 0028-0836

VL - 323

SP - 558

EP - 560

JO - Nature

JF - Nature

IS - 6088

ER -

The hepatitis delta (δ) virus possesses a circular RNA

Abstract

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