TY - JOUR
T1 - The ENDpoiNTs Project
T2 - Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
AU - Lupu, Diana
AU - Andersson, Patrik
AU - Bornehag, Carl-Gustaf
AU - Demeneix, Barbara
AU - Fritsche, Ellen
AU - Gennings, Chris
AU - Lichtensteiger, Walter
AU - Leist, Marcel
AU - Leonards, Pim E G
AU - Ponsonby, Anne-Louise
AU - Scholze, Martin
AU - Testa, Giuseppe
AU - Tresguerres, Jesus A F
AU - Westerink, Remco H S
AU - Zalc, Bernard
AU - Rüegg, Joëlle
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
AB - Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
KW - Animals
KW - Endocrine Disruptors/toxicity
KW - Endocrine System/drug effects
KW - Environmental Exposure/adverse effects
KW - Environmental Monitoring/standards
KW - Guidelines as Topic
KW - Humans
KW - Mice
KW - Nervous System/drug effects
KW - Neurons/metabolism
KW - Rats
KW - Risk Assessment
KW - Toxicity Tests/standards
KW - Transcriptome
U2 - 10.3390/ijms21113978
DO - 10.3390/ijms21113978
M3 - Article
C2 - 32492937
SN - 1661-6596
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
M1 - 3978
ER -
