TY - JOUR
T1 - The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa—
T2 - A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial
AU - Gröbner, E.M.
AU - Zeiler, M.
AU - Fischmeister, F.Ph.S.
AU - Kollndorfer, K.
AU - Schmelz, S.
AU - Schneider, A.
AU - Haid-Stecher, N.
AU - Sevecke, K.
AU - Wagner, G.
AU - Keller, L.
AU - Adan, R.
AU - Danner, U.N.
AU - van Elburg, A.A.
AU - van der Vijgh, B.
AU - Kooij, K.L.
AU - Fetissov, S.
AU - Andreani, N.A.
AU - Baines, J.F.
AU - Dempfle, A.
AU - Seitz, J.
AU - Herpertz-Dahlmann, B.
AU - Karwautz, A.
N1 - Funding Information:
The authors thank all patients and their caregivers who participated in this study. This research was funded by ERANET‐NEURON 2018, grant number MIGBAN FKZ: 01EW1906A and Austrian Science Foundation, I 4184B (21 December 2018).
Publisher Copyright:
© 2021 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Objective: Knowledge on gut–brain interaction might help to develop new therapies for patients with anorexia nervosa (AN), as severe starvation-induced changes of the microbiome (MI) do not normalise with weight gain. We examine the effects of probiotics supplementation on the gut MI in patients with AN. Method: This is a study protocol for a two-centre double-blind randomized-controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment-as-usual compared to placebo in 60 patients with AN (13–19 years). Moreover, 60 sex- and age-matched healthy controls are included in order to record development-related changes. Assessments are conducted at baseline, discharge, 6 and 12 months after baseline. Assessments include measures of body mass index, psychopathology (including eating-disorder-related psychopathology, depression and anxiety), neuropsychological measures, serum and stool analyses. We hypothesise that probiotic administration will have positive effects on the gut microbiota and the treatment of AN by improvement of weight gain, gastrointestinal complaints and psychopathology, and reduction of inflammatory processes compared to placebo. Conclusions: If probiotics could help to normalise the MI composition, reduce inflammation and gastrointestinal discomfort and increase body weight, its administration would be a readily applicable additional component of multi-modal AN treatment.
AB - Objective: Knowledge on gut–brain interaction might help to develop new therapies for patients with anorexia nervosa (AN), as severe starvation-induced changes of the microbiome (MI) do not normalise with weight gain. We examine the effects of probiotics supplementation on the gut MI in patients with AN. Method: This is a study protocol for a two-centre double-blind randomized-controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment-as-usual compared to placebo in 60 patients with AN (13–19 years). Moreover, 60 sex- and age-matched healthy controls are included in order to record development-related changes. Assessments are conducted at baseline, discharge, 6 and 12 months after baseline. Assessments include measures of body mass index, psychopathology (including eating-disorder-related psychopathology, depression and anxiety), neuropsychological measures, serum and stool analyses. We hypothesise that probiotic administration will have positive effects on the gut microbiota and the treatment of AN by improvement of weight gain, gastrointestinal complaints and psychopathology, and reduction of inflammatory processes compared to placebo. Conclusions: If probiotics could help to normalise the MI composition, reduce inflammation and gastrointestinal discomfort and increase body weight, its administration would be a readily applicable additional component of multi-modal AN treatment.
KW - anorexia nervosa
KW - gut microbiome
KW - gut–brain axis
KW - probiotics
KW - randomized controlled trial
U2 - 10.1002/erv.2876
DO - 10.1002/erv.2876
M3 - Article
C2 - 34851002
AN - SCOPUS:85120338210
SN - 1072-4133
VL - 30
SP - 61
EP - 74
JO - European Eating Disorders Review
JF - European Eating Disorders Review
IS - 1
ER -