The effect of recombinant human interferon α B/D compared to interferon α 2b on SIV infection in rhesus macaques.

H. Schellekens; H. Niphuis; L. Buijs; P. Douw Van Der Krap; H.K. Hochkeppel; J.L. Heeney

doi:10.1016/0166-3542(95)00955-8

The effect of recombinant human interferon α B/D compared to interferon α 2b on SIV infection in rhesus macaques.

H. Schellekens
, H. Niphuis
, L. Buijs
, P. Douw Van Der Krap
, H.K. Hochkeppel
, J.L. Heeney

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon α, Hu IFN-α 2b and Hu IFN-α B/D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Antiviral Research
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0166-3542(95)00955-8
Publication status	Published - 1 Aug 1996
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AIDS
HIV
Interferon
Rhesus monkey
SIV
recombinant alpha interferon
recombinant alpha2b interferon
recombinant alphab/d interferon
unclassified drug
animal experiment
article
controlled study
drug effect
drug efficacy
nonhuman
priority journal
rhesus monkey
Simian immunodeficiency virus

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10.1016/0166-3542(95)00955-8

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title = "The effect of recombinant human interferon α B/D compared to interferon α 2b on SIV infection in rhesus macaques.",

abstract = "The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon α, Hu IFN-α 2b and Hu IFN-α B/D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.",

keywords = "AIDS, HIV, Interferon, Rhesus monkey, SIV, recombinant alpha interferon, recombinant alpha2b interferon, recombinant alphab/d interferon, unclassified drug, animal experiment, article, controlled study, drug effect, drug efficacy, nonhuman, priority journal, rhesus monkey, Simian immunodeficiency virus",

author = "H. Schellekens and H. Niphuis and L. Buijs and \{Douw Van Der Krap\}, P. and H.K. Hochkeppel and J.L. Heeney",

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AU - Schellekens, H.

AU - Niphuis, H.

AU - Buijs, L.

AU - Douw Van Der Krap, P.

AU - Hochkeppel, H.K.

AU - Heeney, J.L.

PY - 1996/8/1

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N2 - The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon α, Hu IFN-α 2b and Hu IFN-α B/D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.

AB - The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon α, Hu IFN-α 2b and Hu IFN-α B/D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.

KW - AIDS

KW - HIV

KW - Interferon

KW - Rhesus monkey

KW - SIV

KW - recombinant alpha interferon

KW - recombinant alpha2b interferon

KW - recombinant alphab/d interferon

KW - unclassified drug

KW - animal experiment

KW - article

KW - controlled study

KW - drug effect

KW - drug efficacy

KW - nonhuman

KW - priority journal

KW - rhesus monkey

KW - Simian immunodeficiency virus

U2 - 10.1016/0166-3542(95)00955-8

DO - 10.1016/0166-3542(95)00955-8

M3 - Article

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VL - 32

SP - 1

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JO - Antiviral Research

JF - Antiviral Research

IS - 1

ER -

The effect of recombinant human interferon α B/D compared to interferon α 2b on SIV infection in rhesus macaques.

Abstract

UN SDGs

Keywords

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