Abstract
Feather-pecking behavior in laying hens (Gallus gallus) may be considered a behavioral pathology, comparable to human psychopathological disorders. Scientific knowledge on the causation of such disorders strongly suggests involvement of the serotonergic (5-hydroxytryptamine; 5-HT) system in feather pecking. Previously, chicks from a high-feather-pecking (HFP) line were found to display lower 5-HT turnover levels than chicks from a low-feather-pecking (LFP) line (in response to acute stress; Y. M. van Hierden et al., 2002). The present study investigated whether low 5-HT neurotransmission modulates feather pecking. First, S-15535, a somatodendritic 5-HT1A autoreceptor agonist, was demonstrated to be an excellent tool for reducing 5-HT turnover in the forebrain of LFP and HFP chicks. Second, the most effective dose of S-15535 (4.0 mg/kg body weight) significantly increased severe feather-pecking behavior. The results confirmed the postulation that the performance of feather pecking is triggered by low 5-HT neurotransmission.
| Original language | English |
|---|---|
| Pages (from-to) | 575-583 |
| Number of pages | 9 |
| Journal | Behavioral Neuroscience |
| Volume | 118 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2004 |
Keywords
- OBSESSIVE-COMPULSIVE DISORDER
- LAYING HENS
- 5-HT1A AUTORECEPTORS
- DOPAMINERGIC-NEURONS
- (5-HT)(1A) RECEPTORS
- MANUAL RESTRAINT
- S 15535
- MICE
- MODULATION
- TURNOVER