The components of the proteasome system and their role in MHC class I antigen processing

E Krüger, U. Kuckelkorn, A Sijts, Peter M Kloetzel

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    By generating peptides from intracellular antigens which are then presented to T cells, the ubiquitin/26S proteasome system plays a central role in the cellular immune response. The proteolytic properties of the proteasome are adapted to the requirements of the immune system by proteasome components whose synthesis is under the control of interferon-gamma. Among these are three subunits with catalytic sites that are incorporated into the enzyme complex during its de novo synthesis. Thus, the proteasome assembly pathway and the formation of immunoproteasomes play a critical regulatory role in the regulation of the proteasome's catalytic properties. In addition, interferon-gamma also induces the synthesis of the proteasome activator PA28 which, as part of the so-called hybrid proteasome, exerts a more selective function in antigen presentation. Consequently, the combination of a number of regulatory events tunes the proteasome system to gain maximal efficiency in the generation of peptides with regard to their quality and quantity.

    Original languageEnglish
    Pages (from-to)81-104
    Number of pages24
    JournalReviews of physiology, biochemistry and pharmacology
    Volume148
    DOIs
    Publication statusPublished - 2003

    Keywords

    • Animals
    • Cysteine Endopeptidases
    • Histocompatibility Antigens Class I
    • Multienzyme Complexes
    • Proteasome Endopeptidase Complex
    • Journal Article
    • Review

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