The alloherpesviral counterparts of interleukin 10 in European eel and common carp

Steven J van Beurden; Maria Forlenza; Adrie H Westphal; Geert F Wiegertjes; Olga L M Haenen; Marc Y Engelsma

doi:10.1016/j.fsi.2011.08.004

The alloherpesviral counterparts of interleukin 10 in European eel and common carp

Steven J van Beurden, Maria Forlenza, Adrie H Westphal, Geert F Wiegertjes, Olga L M Haenen, Marc Y Engelsma

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.

Original language	English
Pages (from-to)	1211-7
Number of pages	7
Journal	Fish & shellfish immunology
Volume	31
Issue number	6
DOIs	https://doi.org/10.1016/j.fsi.2011.08.004
Publication status	Published - Dec 2011

Bibliographical note

Keywords

Amino Acid Sequence
Animals
Base Sequence
Carps
Cluster Analysis
Crystallography
DNA Primers
DNA Viruses
Eels
Evolution, Molecular
Interleukin-10
Models, Genetic
Models, Molecular
Molecular Sequence Data
Open Reading Frames
Phylogeny
Sequence Analysis, DNA
Sequence Homology

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10.1016/j.fsi.2011.08.004

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title = "The alloherpesviral counterparts of interleukin 10 in European eel and common carp",

abstract = "Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.",

keywords = "Amino Acid Sequence, Animals, Base Sequence, Carps, Cluster Analysis, Crystallography, DNA Primers, DNA Viruses, Eels, Evolution, Molecular, Interleukin-10, Models, Genetic, Models, Molecular, Molecular Sequence Data, Open Reading Frames, Phylogeny, Sequence Analysis, DNA, Sequence Homology",

author = "{van Beurden}, {Steven J} and Maria Forlenza and Westphal, {Adrie H} and Wiegertjes, {Geert F} and Haenen, {Olga L M} and Engelsma, {Marc Y}",

year = "2011",

month = dec,

doi = "10.1016/j.fsi.2011.08.004",

language = "English",

volume = "31",

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journal = "Fish & shellfish immunology",

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AU - van Beurden, Steven J

AU - Forlenza, Maria

AU - Westphal, Adrie H

AU - Wiegertjes, Geert F

AU - Haenen, Olga L M

AU - Engelsma, Marc Y

PY - 2011/12

Y1 - 2011/12

N2 - Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.

AB - Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Carps

KW - Cluster Analysis

KW - Crystallography

KW - DNA Primers

KW - DNA Viruses

KW - Eels

KW - Evolution, Molecular

KW - Interleukin-10

KW - Models, Genetic

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Open Reading Frames

KW - Phylogeny

KW - Sequence Analysis, DNA

KW - Sequence Homology

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DO - 10.1016/j.fsi.2011.08.004

M3 - Article

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SN - 1050-4648

VL - 31

SP - 1211

EP - 1217

JO - Fish & shellfish immunology

JF - Fish & shellfish immunology

IS - 6

ER -

The alloherpesviral counterparts of interleukin 10 in European eel and common carp

Abstract

Bibliographical note

Keywords

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