Ternary Copper(II) Coordination Compounds with Nonpolar Amino Acids and 2,2′-Bipyridine: Monomers vs. Polymers

Darko Vusak, Katarina Lezaic, Nenad Judas, Biserka Prugovecki

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Reactions of copper(II) sulfate with 2,2′-bipyridine (bipy) and amino acids with nonpolar side chains (l-alanine (HAla), l-valine (HVal), or l-phenylalanine (HPhe)) were investigated under different solution-based and mechanochemical methods. Five new ternary coordination compounds were obtained by a solution-based synthesis and three of them additionally by the liquid-assisted mechanochemical method: {[Cu(μ-l-Ala)(H2O)(bipy)]2SO4·2H2O}n (1a·2H2O), {[Cu(μ-l-Ala)(H2O)(bipy)][Cu(l-Ala)(H2O)(bipy)]SO4·2.5H2O}n (1b·2.5H2O), {[Cu(μ-l-Val)(H2O)(bipy)][Cu(l-Val)(H2O)(bipy)]3(SO4)2·4H2O}n (2·4H2O), [Cu(l-Phe)(H2O)(bipy)][Cu(l-Phe)(SO4)(bipy)]∙8H2O (3·8H2O), and [Cu(l-Phe)(H2O)(bipy)][Cu(l-Phe)(SO4)(bipy)]∙9H2O (3·9H2O). The compounds were characterized by single-crystal and powder X-ray diffraction, infrared spectroscopy, and a thermal analysis. Structural studies revealed two structural types, monomeric in 3·8H2O and 3·9H2O, polymeric architectures in 1a·2H2O, and mixed structures (monomeric and polymeric) in 1b·2.5H2O and 2·4H2O. The copper(II) ion is either pentacoordinated or hexacoordinated, with an observed Jahn–Teller effect. The crystal structures are based on an intensive network of hydrogen bonds and π interactions. 1a·2H2O and 2·4H2O showed substantial in vitro antiproliferative activity toward human hepatocellular carcinoma (HepG2) and moderate activity toward human acute monocytic leukemia cell lines (THP-1).
Original languageEnglish
Article number656
Pages (from-to)1-15
Number of pages15
JournalCrystals
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Funding

This research was funded by project CIuK, which was co-financed by the Croatian Government and the European Union through the European Regional Development Fund\u2013Competitiveness and Cohesion Operational Programme (Grant KK.01.1.1.02.0016) and by an institutional project financed by the University of Zagreb entitled Synthesis and Structural Characterization of Organic and Complex Compounds: Protein Structure.

FundersFunder number
European Commission
European Regional Development FundKK.01.1.1.02.0016

    Keywords

    • 2,2 '-bipyridine
    • Amino acids
    • Coordination polymers
    • Copper
    • Crystal structures
    • Mechanochemistry
    • Solution-based synthesis
    • Ternary coordination compounds

    Fingerprint

    Dive into the research topics of 'Ternary Copper(II) Coordination Compounds with Nonpolar Amino Acids and 2,2′-Bipyridine: Monomers vs. Polymers'. Together they form a unique fingerprint.

    Cite this