Targets for the induction of protective immunity against influenza a viruses

Rogier Bodewes, Albert D M E Osterhaus, Guus F Rimmelzwaan

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The current pandemic caused by the new influenza A(H1N1) virus of swine origin and the current pandemic threat caused by the highly pathogenic avian influenza A viruses of the H5N1 subtype have renewed the interest in the development of vaccines that can induce broad protective immunity. Preferably, vaccines not only provide protection against the homologous strains, but also against heterologous strains, even of another subtype. Here we describe viral targets and the arms of the immune response involved in protection against influenza virus infections such as antibodies directed against the hemagglutinin, neuraminidase and the M2 protein and cellular immune responses directed against the internal viral proteins.

    Original languageEnglish
    Pages (from-to)166-88
    Number of pages23
    JournalViruses [E]
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - Jan 2010

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