Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

Frank Reichel; Peter R. Ashton; Geert Jan Boons

doi:10.1039/a704127f

Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

Frank Reichel, Peter R. Ashton, Geert Jan Boons^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A facile and highly efficient synthesis of a glycopeptidolipid containing a heptose sugar, a synthetic T-epitope and a synthetic immunoadjuvant is presented which represents an important step towards the development of a fully synthetic vaccine against Neisseria meningitidis.

Original language	English
Pages (from-to)	2087-2088
Number of pages	2
Journal	Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/a704127f
Publication status	Published - 7 Nov 1997
Externally published	Yes

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10.1039/a704127f

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title = "Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate",

abstract = "A facile and highly efficient synthesis of a glycopeptidolipid containing a heptose sugar, a synthetic T-epitope and a synthetic immunoadjuvant is presented which represents an important step towards the development of a fully synthetic vaccine against Neisseria meningitidis.",

author = "Frank Reichel and Ashton, {Peter R.} and Boons, {Geert Jan}",

year = "1997",

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doi = "10.1039/a704127f",

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AU - Reichel, Frank

AU - Ashton, Peter R.

AU - Boons, Geert Jan

PY - 1997/11/7

Y1 - 1997/11/7

N2 - A facile and highly efficient synthesis of a glycopeptidolipid containing a heptose sugar, a synthetic T-epitope and a synthetic immunoadjuvant is presented which represents an important step towards the development of a fully synthetic vaccine against Neisseria meningitidis.

AB - A facile and highly efficient synthesis of a glycopeptidolipid containing a heptose sugar, a synthetic T-epitope and a synthetic immunoadjuvant is presented which represents an important step towards the development of a fully synthetic vaccine against Neisseria meningitidis.

U2 - 10.1039/a704127f

DO - 10.1039/a704127f

M3 - Article

AN - SCOPUS:0030846933

SN - 1359-7345

SP - 2087

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JO - Chemical Communications

JF - Chemical Communications

IS - 21

ER -

Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

Abstract

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