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Synthetic and Mechanistic Studies with Lipopeptide Antibiotics
L.H.J. Kleijn
Afd Chemical Biology and Drug Discovery
Chemical Biology and Drug Discovery
Research output
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Thesis
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Doctoral thesis 1 (Research UU / Graduation UU)
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Keyphrases
Nisin
100%
Synthetic Study
100%
Lipopeptide Antibiotics
100%
Mechanistic Studies
100%
Lipopeptide
50%
Natural Products
50%
Antibiotics
33%
Mode of Action
33%
Drug-like
33%
Clinically Significant
16%
Clinical Development
16%
Lipids
16%
Post-translational Modification
16%
Bacterial Membrane
16%
Working Mechanism
16%
Structural Diversity
16%
Antibiotic Property
16%
Lipid II
16%
Natural Antibiotics
16%
Peptide Macrocycles
16%
Cyclic Peptide
16%
Nonribosomal
16%
Binder
16%
Biosynthetic Pathway
16%
Chemical Modification
16%
Recent Introduction
16%
Achilles Heel
16%
Bacterial Cell Wall Synthesis
16%
Phospholipid Precursor
16%
Soil-inhabiting
16%
Polymyxin
16%
Natural Product Derivatives
16%
Ribosome Synthesis
16%
First Synthesis
16%
Chemical Derivatives
16%
Antibiotic Modes of Action
16%
Lipoglycopeptide
16%
Chemistry
Mechanistic Study
100%
Lipopeptide Antibiotic
100%
Nisin
100%
Occurrence in Nature
83%
Lipopeptide
66%
Structure
16%
Crystal Structure
16%
Macrocycle
16%
Polymyxin
16%
Phospholipid
16%
Lipid II
16%
Pharmacology, Toxicology and Pharmaceutical Science
Lipopeptide Antibiotics
100%
Nisin
100%
Natural Product
83%
Lipopeptide
66%
Antibiotics
50%
Antibiotic Agent
33%
Macrocyclic Compound
16%
Polymyxin
16%
Phospholipid
16%